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ProteomicsHsp70 ATP-dependent dimerization and Chaperone/Co-chaperone Interactions
Eukaryotic protein homeostasis (proteostasis) is largely dependent on the action of highly conserved Hsp70 molecular chaperones. Recent evidence indicates that apart from conserved molecular allostery, Hsp70 proteins retained and adapted throughout the evolution the ability to assemble as functional...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010069 | Pride
Tomm34 Hsp70 Co-chaperone Dimer Chip 
ProteomicsStructural basis of chaperone regulation by a post-translational modification
The Hsp70 chaperone BiP is covalently modified with adenosine monophosphate (referred to as AMPylation) in order to adapt its activity to the fluctuating folding load within the endoplasmic reticulum. This modification is catalyzed by the only human representative of the family of filamentation indu...
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022869 | Pride
Hype Ampylation Hsp70 chaperone bip 
UnknownHSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.
Not available
S-EPMC5632570 | biostudies-literature
UnknownClose and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP.
Not available
S-EPMC4680848 | biostudies-literature
UnknownConformational plasticity of a BiP-GRP94 chaperone complex.
Not available
S-EPMC12527940 | biostudies-literature
UnknownAllosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation.
Not available
S-EPMC5655141 | biostudies-literature
UnknownChaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.
Not available
S-EPMC11300964 | biostudies-literature
UnknownUPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor.
Not available
S-EPMC6858872 | biostudies-literature
TranscriptomicsNew compounds triggering endoplasmic reticulum stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
We discovered and developed a new series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all tested melanoma cells including those isolated from patients and those that developed resistance to BRAF inhibitors. Our molecule dis...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79071 | biostudies-arrayexpress
GenomicsBombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BIP
Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BIP
PRJNA1138767 | ENA
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