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ProteomicsA Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery
Purines are essential bioactive molecules that interact with a large fraction of the human proteome. Despite their importance, the scope of actionable purine-binding pockets for ligand discovery remains limited. Here, we developed a quantitative chemoproteomics platform using sulfonyl-purine (SuPUR)...
ORGANISM(S): Homo sapiens (Human) 
2026-03-29 | PXD075707 | Pride
ProteomicsA Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery
Purines are essential bioactive molecules that interact with a large fraction of the human proteome. Despite their importance, the scope of actionable purine-binding pockets for ligand discovery remains limited. Here, we developed a quantitative chemoproteomics platform using sulfonyl-purine (SuPUR)...
ORGANISM(S): Homo sapiens (Human) 
2026-03-29 | PXD071955 | Pride
ProteomicsChemoproteomic capture of RNA binding activity in living cells
Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at individual binding sites by RIC, however, has been more ch...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD044625 | Pride
Lc-msms Chemoproteomics Human Chemical biology Rna-binding protein Rna interactome 
ProteomicsEndocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
Diacylglycerol lipase-beta (DAGLβ) serves as a principal 2-arachidonoylglycerol (2-AG) biosynthetic enzyme regulating endocannabinoid and eicosanoid metabolism in immune cells including macrophages and dendritic cells. Genetic or pharmacological inactivation of DAGLβ ameliorates inflammation and hyp...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-02 | PXD047413 | Pride
Inflammation Ampk Endocannabinoids Diacylglycerol lipase Activity based protein profiling 
ProteomicsGlobal profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation
RNA granules are cytoplasmic condensates that organize biochemical and signaling complexes in response to cellular stress. Functional proteomic investigations under RNA granule-inducing conditions are needed to identify protein sites involved in coupling stress response with ribonucleoprotein regula...
ORGANISM(S): Homo sapiens (Human) 
2023-10-23 | PXD038010 | Pride
Lc-msms Stress granules Llps Sutex P-bodies Stress Chemoproteomics Rna granule Condensate Tyrosine Edc3 
UnknownLarge-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.
Not available
S-EPMC12754705 | biostudies-literature
UnknownMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Not available
S-EPMC5968830 | biostudies-literature
UnknownMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Not available
S-EPMC6467258 | biostudies-literature
UnknownMultiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
Not available
S-EPMC6545280 | biostudies-literature
UnknownShared heritability and functional enrichment across six solid cancers.
Not available
S-EPMC6347624 | biostudies-literature
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