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UnknownDevelopment and biological applications of sulfur-triazole exchange (SuTEx) chemistry.
Not available
S-EPMC8174820 | biostudies-literature
UnknownDiscovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2.
Not available
S-EPMC8206015 | biostudies-literature
UnknownChemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes.
Not available
S-EPMC8179411 | biostudies-literature
ProteomicsChemical proteomics with novel fully functionalized fragments and stringent target prioritization identifies the glutathione-dependent isomerase GSTZ1 as a lung cancer target: SuTEx of GSTZ1 KD
Photoreactive fragment-like probes have been applied to discover target proteins that constitute novel cellular vulnerabilities and to identify viable chemical hits for drug discovery. Through forming covalent bonds, functionalized probes can achieve stronger target engagement and require less effor...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD037894 | Pride
Fragment-based drug discovery Gstz1 Lung cancer Chemical proteomics 
ProteomicsGlobal profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation
RNA granules are cytoplasmic condensates that organize biochemical and signaling complexes in response to cellular stress. Functional proteomic investigations under RNA granule-inducing conditions are needed to identify protein sites involved in coupling stress response with ribonucleoprotein regula...
ORGANISM(S): Homo sapiens (Human) 
2023-10-23 | PXD038010 | Pride
Lc-msms Stress granules Llps Sutex P-bodies Stress Chemoproteomics Rna granule Condensate Tyrosine Edc3 
UnknownLiganding Functional Tyrosine Sites on Proteins Using Sulfur-Triazole Exchange Chemistry.
Not available
S-EPMC7332231 | biostudies-literature
UnknownGlobal targeting of functional tyrosines using sulfur-triazole exchange chemistry.
Not available
S-EPMC6982592 | biostudies-literature
UnknownHuman PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages.
Not available
S-EPMC12710877 | biostudies-literature
ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
ProteomicsChemical proteomics with novel fully functionalized fragments and stringent target prioritization identifies the glutathione-dependent isomerase GSTZ1 as a lung cancer target
Photoreactive fragment-like probes have been applied to discover target proteins that constitute novel cellular vulnerabilities and to identify viable chemical hits for drug discovery. Through forming covalent bonds, functionalized probes can achieve stronger target engagement and require less effor...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD035201 | Pride
Photoreactive probes Lung cancer Gstz1 Chemical proteomics 
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