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ProteomicsSerum proteomic characterization of dengue patients
In the present study, we performed a quantitative proteomic analysis of serum from 19 patients with dengue and 11 healthy people. The results revealed distinct proteomic landscapes between the two groups.
ORGANISM(S): Homo sapiens (Human) 
2024-08-29 | PXD052720 | Pride
Human Lc-msms Dengue 
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD064850 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
UnknownUnraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression.
Not available
S-EPMC10964850 | biostudies-literature
UnknownDrug resistance patterns and genotype associations of Trichomonas gallinae in meat pigeons (Columba livia): insights from Guangdong Province, China.
Not available
S-EPMC10803545 | biostudies-literature
ProteomicsDe novo designed protein guiding targeted protein degradation
Targeted protein degradation is a powerful tool for biological research, cell therapy, and synthetic biology. However, conventional methods often depend on pre-fused degrons or chemical degraders, limiting their wider applications. In this study, a guided protein labeling and degradation system (GPl...
ORGANISM(S): Escherichia coli 
2025-07-05 | PXD063956 | Pride
Protein degradation  protein design 
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by activating cholesterol biosynthesis in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD054740 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
ProteomicsJosephin Domain Containing 2 (JOSD2) Inhibition as Pan-KRAS-Mutation-Targeting Strategy for Colorectal Cancer
KRAS is the most common mutated oncogenes in colorectal cancer (CRC), yet effective therapeutic strategies for targeting multiple KRAS-mutations remained challenging. The prolonged protein stability of KRAS mutants contribute to their robust tumor-promoting effects, but the underlying mechanism is e...
ORGANISM(S): Homo sapiens (Human) 
2025-03-01 | PXD054525 | Pride
Deubiquitinases Ubiquitination. Josd2 Kras Colorectal cancer 
ProteomicsMouse cortex immunoprecipitation-mass spectrometry
To determine the mechanism for how Kctd10 deficiency impacts brain development, co-immunoprecipitation (co-IP) was performed to identify KCTD10-interacting proteins from the E14.5 cerebral cortex using a KCTD10 antibody, followed by mass spectrometric analysis. In total, 143 proteins uniquely precip...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD050135 | Pride
E14.5 Mouse Kctd10 Crebral cortex 
ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
Proteomics4DLabelfree quantitative acetylation of modified proteome in Toxoplasma gondii protein fluid samples
A series of advanced techniques such as protein extraction, enzyme digestion, enrichment of modified peptide, tandem analysis of liquid chromatography-mass spectrometry and bioinformation analysis were used to study the modified quantitative omics of the samples.
ORGANISM(S): Toxoplasma gondii GT1 
2026-09-14 | PXD052656 | Pride
Toxoplasma acetylation 
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