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ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
UnknownPolymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.
Not available
S-EPMC4394094 | biostudies-literature
UnknownRAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population.
Not available
S-EPMC3942844 | biostudies-literature
Proteomicsstreptococcus suis LC-MS/MS - MnmE, a Central tRNA-Modifying GTPase, Is Essential for the Growth, Pathogenicity, and Arginine Metabolism of Streptococcus suis Serotype 2
Streptococcus suis is an important pathogen in pigs and can also cause severe infections in humans. However, little is known about proteins associated with cell growth and virulence of S. suis. In this study, a GTPase MnmE homologue was identified in a Chinese isolate (SC19) that drives a tRNA modif...
ORGANISM(S): Streptococcus suis SC149 
2019-11-13 | PXD012716 | Pride
Ss2 Tmt Mnme 
UnknownRelationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma.
Not available
S-EPMC4917616 | biostudies-literature
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
TranscriptomicsChanges of the gene expression profiling induced by fenofibrate
To make investigation of the apoptosis-inducing effect of fenofibrate, the Gene expression profile chip was used to compare the changes between the control group (0M-NM-
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-49965 | biostudies-arrayexpress
UnknownUniversal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways.
Not available
S-EPMC11948844 | biostudies-literature
ProteomicsDeciphering the logic of mammalian mitochondrially-localised translation
Localised translation broadly enables spatiotemporal control of gene expression yet currently there are limited tools for monitoring subcellular translation in mammalian cells. Here we present LOCL-TL (LOV-domain Controlled Ligase for Translation Localisation) an optogenetic approach for labelling r...
ORGANISM(S): Homo sapiens (Human) 
2025-07-29 | PXD054646 | Pride
Human Mitochondria Localised translation 
UnknownMYC-induced reprogramming of glutamine catabolism supports optimal virus replication.
Not available
S-EPMC4660206 | biostudies-literature
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