Sort   by:  
 Page size 
The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long non-coding RNAs (lncRNAs), which regulate gene expression with little or no protein...
ORGANISM(S): Mus musculus 
To better understand human ATP13A2-mediated polyamine transport, we used single-particle cryo-electron microscopy to solve high-resolution structures of human ATP13A2. Interestingly, we found polyamine binding at multiple sites distributed along the transmembrane regions in ATP13A2 protein, which ha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037493 | Pride
This project aims to elucidate a novel molecular mechanism driving mechanical allodynia, a debilitating neuropathic pain condition. We focus on a spinal cord “allodynia gate” circuit in which nerve injury leads to disinhibition of protein kinase Cγ (PKCγ) excitatory neurons. Our findings reveal that...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070478 | Pride
Toxoplasma gondii is an obligate intracellular protozoan parasite that poses a severe threat to human health, especially those immune-compromised individuals. Sulfadiazine sodium (SDZ) is widely used for the treatment of human toxoplasmosis. However, systems biology researches on the therapeutic eff...
2019-06-18 | MTBLS852 | MetaboLights
Gall-forming insects manipulate host plants through the proteins present in their saliva, which play essential roles in reprogramming plant cells. Understanding the salivary composition of these insects is crucial for revealing the mechanisms underlying gall induction and the interactions between he...
ORGANISM(S): Trioza sp. 8 NS74B 
2025-07-25 | PXD045317 | Pride
Sort   by:  
 Page size