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MetabolomicsMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. ...

2026-01-28 | MTBLS8713 | MetaboLights
MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
TranscriptomicsIdentification of Common Genetic Variants that Account for Transcript Isoform Variation between Human Populations
In addition to the differences between populations in transcriptional and translational regulation of genes, alternative pre-mRNA splicing (AS) is also likely to play an important role in regulating gene expression and generating variation in mRNA and protein isoforms. Recently, the genetic contribu...
ORGANISM(S): Homo sapiens 
2010-08-19 | E-GEOD-9703 | biostudies-arrayexpress
UnknownA mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics.
Not available
S-EPMC12766204 | biostudies-literature
TranscriptomicsMicroRNA-674-5p/5-LO axis is important in concanavalin A-induced acute mouse liver injury
Eight-week-old male pathogen-free BALB/c mice were used for the induction of concanavalin A (Con A)-induced hepatitis. Animals were acclimated for at least 6-7 days to a 12-hour light/dark cycle in a humidity- and temperature-controlled, specific-pathogen-free environment in autoclaved cages. Mice w...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-76345 | biostudies-arrayexpress
UnknownKupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice.
Not available
S-EPMC8564511 | biostudies-literature
ProteomicsActivation of GPCR ligand binding genes revealed through degradation of RNA polymerase II
RNA polymerase II drives mRNA gene expression, yet our understanding of global Pol II repression is limited. Using auxin-inducible degron, we degraded Pol II's RPB1 subunit in mESCs, resulting in global repression, yet certain genes exhibited increased RNA levels post-degradation. These genes are as...
ORGANISM(S): Mus Musculus 
PXD048023 |
ProteomicsExtracellular Vesicle Biomarkers for Complement System Dysfunction in Schizophrenia
Schizophrenia has a high rate of misdiagnosis, leading to inappropriate or delayed treatment. Combining with extracellular vesicles’ (EVs) proteome profiling and XGBoost-based machine learning, we developed new pan-EVs markers and yielded personalized discrimination scores (PDS) for schizophrenia di...
ORGANISM(S): Homo Sapiens 
2023-02-20 | PXD040261 |
ProteomicsUrinary proteomics of bladder cancer
LC-MS/MS was used to perform proteomic analysis of preoperative and postoperative urine samples of patients with bladder cancer
ORGANISM(S): Homo Sapiens 
2018-11-29 | PXD011871 |
ProteomicsMulti-Omics Integration Highlights the Role of Ubiquitination in Endometriosis Fibrosis
In this study, we comprehensively profiled the ubiquitination landscape of endometriosis for the first time. Through proteomics, transcriptomics, and ubiquitylomics analyses of endometrial tissues from two patient cohorts, we uncovered significant dysregulation of ubiquitin-related enzymes and ubiqu...
ORGANISM(S): Homo Sapiens 
PXD036497 |
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