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MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
ProteomicsRat hippocampal neurons' proteomes
We induced over-expression and under-expression of Camk2b in cultured rat hippocampal neurons through transfection with lentivirus plasmids. Then isobaric tag for relative and absolute quantitation (iTRAQ)-based quantitative proteomics followed by bioinformatics analyses were carried out to explore...
ORGANISM(S): Rattus Norvegicus 
2022-07-27 | PXD033931 |
ProteomicsSelective identification of epigenetic regulators at methylated genomic sites by SelectID
Identification and quantification of biotinylated proteins enriched by the Sp-system at Chromosome 9 Satellite regions using TMT-labeled quantitative mass spectrometry
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061483 |
ProteomicsValidation of α-satellite-associated regulators using the dCas9-TurboID system in HeLa cells
To validate whether the dCas9-TurboID system is applicable for proximity labeling at specific genomic regions, label-free mass spectrometry was employed to validate the satellite relative proteins that were enriched in the group of stable Hela cell line expressing sgAS.
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061518 |
ProteomicsSelective identification of epigenetic regulators at methylated genomic sites
We applied SelectID coupled with the ultra-sensitive micro-DIA approach to enrich the associated proteins of Chromosome 9 satellite region and methylated LINE-1 elements.
ORGANISM(S): Homo Sapiens 
2025-03-08 | PXD061627 |
ProteomicsProteomics of post-mortem beef tenderization: The role of oxidative stress and peroxiredoxin 6 (Prdx6)
This study explored the role of peroxiredoxin 6 (Prdx6) non-selenium glutathione peroxidase (NSGPx) activity on the regulation of beef tenderization during post-mortem aging periods of up to 168 h. Shear force, NSGPx activity, differential protein expression, heat shock protein 70 (HSP70), heat shoc...
ORGANISM(S): Bos Taurus 
2025-01-28 | PXD060488 |
ProteomicsProtemic analysis of differential sperm freezability in Mediterranean buffalo
Our study provides an understanding of proteins differences in differential freezability sperm which would ultimately helpful to depict the sperm freezability mechanism of Mediterranean buffalo.
ORGANISM(S): Bubalus Bubalis 
2022-06-06 | PXD034388 |
ProteomicsComparative proteomic and phosphorylated proteomic analyses revealed differences in sperm motility in Mediterranean buffalo
In this study, Mediterranean buffalo semen was used as experimental material, and quantitative proteomics and phosphorylation modification techniques were used to analyze the proteins and phosphorylation sites of Mediterranean buffalo sperm with different motility, so as to further study the protein...
ORGANISM(S): Bos Taurus 
2024-10-22 | PXD055618 |
Proteomicslysine succinylation files of different freezability Mediterranean buffalo sperms.
For the first time this study provides lysine succinylation files of different freezability Mediterranean buffalo sperms.
ORGANISM(S): Bubalus Bubalis 
2021-11-29 | PXD030051 |
ProteomicsBacterial Protoplast-Derived Nanovesicles Carrying CRISPR Cas9 Tools Efficiently Re-educate Tumor-Associated Macrophages for Cancer Immunotherapy
we developed an in vivo CRISPR-Cas9 genome editing system that targets tumor-associated macrophages (TAMs) via bacterial protoplast-derived nanovesicles (NVs) decorated with a pH-responsive PEG conjugated polymer and galactosamine-conjugated ligand
ORGANISM(S): Escherichia Coli Bl21(de3) 
2023-09-20 | PXD045507 |
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