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TranscriptomicsGenome-wide analysis of microRNA expression in Non-small Cell Lung Cancer
Analysis of NSCLC development at microRNA expression level. Results shows that has-miR-96 is significant up-regulated in the cancer tissue compared with the adjacent normal tissue. Illumina Human v2 MicroRNA expression beadchip Total microRNA obtained from 6 paired NSCLC cancer tissue and the adjac...
ORGANISM(S): Homo sapiens 
2012-09-16 | E-GEOD-29248 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in Non-small Cell Lung Cancer
Analysis of NSCLC development at gene expression level. Results shows that obvious activation of cell cycle pathway, and significant repression of cell-cell communication pathways. Illumina HumanHT-12 V4.0 expression beadchip Total RNA obtained from 6 paired NSCLC cancer tissue and the adjacent nor...
ORGANISM(S): Homo sapiens 
2012-09-16 | E-GEOD-29249 | biostudies-arrayexpress
ProteomicsMass spectrometry identification of PPARγ methylation sites
Purified recombinant PPARγ-Flag and PRMT4-His were used for in vitro methyltransferase assay.We separated purified methylated PPARγ proteins by SDS-PAGE, visualized them by staining with Coomassie blue, protein lanes were cut into pieces about 1 mm3, and followed further destained.
ORGANISM(S): Homo Sapiens 
2022-06-27 | PXD034929 |
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
ProteomicsImproving Mass Spectrometry Analysis of Protein Structures with Arginine-Selective Chemical Cross-linkers
we develop a series of arginine selective bifunctional aromatic glyoxal cross-linkers (ArGOs) and demonstrate their ability to cross-link model proteins and a protein complex. We also introduce the first arginine-lysine heterobifunctional cross-linker (KArGO), which provides significantly greater su...
ORGANISM(S): Escherichia Coli 
2019-01-14 | PXD012341 |
ProteomicsProteomic analysis of Hypsibius henanensis sp.nov. suffered from 12C6+ heavy ion radiation based on label-free technology
Tardigrades are a kind of species that can tolerate ultra-high doses of ionizing radiation. Here, we used heavy ions at different doses of 0,200 and 2000Gy to irradiate Hypsibius henanensis sp.nov.. Label-free proteomic identification was performed on the samples, each dose containing 3 repetitions
ORGANISM(S): Tardigrada 
2023-09-20 | PXD045537 |
ProteomicsDetection of betalains from the extracts of H. henanensis sp. nov.
Identification of betalains from the extracts of H. henanensis sp. nov. using untargeted metabolomics.
ORGANISM(S): Tardigrada 
2024-03-22 | PXD050882 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055730 |
ProteomicsDDX5-sIL-36R in keratinocytes controls skin inflammation
The DEAD-box (DDX) proteins function in diverse cellular processes including RNA alternative splicing, and are linked to immune-mediated diseases. However, little is known about the roles of DDXs in skin inflammatory diseases. Here, we show that DDX5, one of the founding members of the DDX RNA helic...
ORGANISM(S): Homo Sapiens 
2020-09-09 | PXD021379 |
TranscriptomicsCritical Role of Sphingolipid Pathway Components in Murine Radiation-Induced Lung Injury: Protection by Sphingosine-1-Phosphate Analogues
Clinically significant radiation-induced lung injury (RILI) is associated with significant morbidity and mortality and a common toxicity in patients administered thoracic radiotherapy. While the molecular etiology of RILI is poorly understood, we previously characterized a murine model of RILI in wh...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-25295 | biostudies-arrayexpress
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