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MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
TranscriptomicsRole of BACH1 in HEK 293T cells
This SuperSeries is composed of the following subset Series: GSE28050: Expression data from knockdown of BACH1 in HEK 293T cells GSE28051: Genome-wide map of BACH1 binding in HEK293T cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-05-12 | E-GEOD-28053 | biostudies-arrayexpress
TranscriptomicsIdentification of genes upregulated by methyl-CpG targeted transcriptional activation (MeTA) in 293T
The identification of genes transcriptionally silenced by DNA hypermethylation is important in understanding the molecular basis of epigenetically regulated biological processes such as X chromosome inactivation, genomic imprinting, and cancer development. Our previously developed methyl-CpG targete...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-25981 | biostudies-arrayexpress
MetabolomicsLipids in the escalated host-pathogen arms race

Lipids, fundamental constituents of cell membranes, cellular energy carriers, and signaling molecules, play a pivotal role in the interaction between pathogens and hosts. During microbial infections, lipids not only fuel the activation of the immune system but also, acting as signaling molec...

2025-07-05 | MTBLS12678 | MetaboLights
TranscriptomicsTranscriptomics analysis of gene expression in normal and METTL3 or WTAP deficient Human 293T cells
RNA was isolated from and METTL3M-oM-
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50582 | biostudies-arrayexpress
TranscriptomicsExpression data from 293T cell treated with ROCK inhibitor
We used microarray to determine the genes whose expression was changed at three or six hours after Y27632 treatment. Three-condition experiment; 293T control vs 293T treated with Y27632 for three hours, 293T control vs 293T treated with Y27632 for six hours.
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-32024 | biostudies-arrayexpress
GenomicsGenome-wide map of BACH1 binding in HEK 293T cells
BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements (MAREs) at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAREs, resulting in increased expression of antioxidant response genes....
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-28051 | biostudies-arrayexpress
GenomicsGenome-wide distribution of UHRF2 and ZNF618 in 293T cells.
We have identified ZNF618 as a novel binding partner of UHRF2. We have found that UHRF2 and ZNF618 co-localize at many genomic loci. Examination of genome-wide distribution of SFB-tagged UHRF2 and ZNF618 in 293T cells using ChIP-seq.
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-80037 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
GenomicsChIP-seq of human 293T cells expressing an HA-tagged SCAN zinc-finger protein
To determine the binding sites of human SCAN zinc-finger proteins (SZFPs), 293T cells transduced to express an HA-tagged SZFP in a doxycycline-inducible manner were cultured in 1 µg/ml doxycycline for 72h and were used for ChIP-seq library preparation.
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-14683 | biostudies-arrayexpress
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