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ProteomicsProteomic analysis of purified human centrosomes
Identification and comparison of protein content of 2 independently prepared fractions of human centrosomes.
ORGANISM(S): Homo sapiens (Human) 
2015-12-16 | PXD003226 | Pride
Human centrosomes Nanolc-ms/ms 
ProteomicsProteomic analysis of purified human centrosomes
Identification and comparison of protein content of 2 independently prepared fractions of human centrosomes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080747 | MassIVE
TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
GenomicsExtra centrosomes delay DNA damage-driven tumorigenesis
Extra centrosomes delay DNA damage-driven tumorigenesis
PRJEB72005 | ENA
TranscriptomicsGene expression comparison of MCF10A cells with and without extra centrosomes through overexpression of PLK4
The presence of extra centrosomes is a feature of human tumours. However, it is unclear what are the changes elicited by the presence of these abnormalities. To determine the changes in gene expression induced by centrosome amplification, human mammary epithelial cells, MCF10A, expressing a doxycycl...
ORGANISM(S): Homo sapiens 
2018-02-10 | E-MTAB-6415 | biostudies-arrayexpress
ProteomicsProteomic profiling of centrosomes across multiple cell and tissue types by a new affinity capture method
Centrosomes are small cytoplasmic organelles that play fundamental roles in a range of cellular processes. Nearly all vertebrate cell types contain centrosomes, but whether centrosome composition and function differ between cell types, tissues and pathologies remains an outstanding question. Until n...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-10-18 | PXD040308 | Pride
Proteomics Capture peptide Capture-ms Centrosomes 
ProteomicsProteomic profiling of centrosomes across multiple cell and tissue types by a new affinity capture method
Centrosomes are small cytoplasmic organelles that play fundamental roles in a range of cellular processes. Nearly all vertebrate cell types contain centrosomes, but whether centrosome composition and function differ between cell types, tissues and pathologies remains an outstanding question. Until n...
ORGANISM(S): Homo sapiens (Human) 
2023-10-18 | PXD040309 | Pride
Proteomics Centrosomes Capture ms 
GenomicsExtra centrosomes delay DNA damage-driven tumorigenesis
Centrosomes act as microtubule organizing centers and are critical for faithful chromosome segregation in mitosis. Deregulated centrosome numbers are frequently found in human cancer and can promote malignancies in model organisms. Current research aims to clarify if extra centrosomes are cause or c...
ORGANISM(S): Mus musculus 
2026-01-22 | E-MTAB-13724 | biostudies-arrayexpress
ProteomicsUncovering structural themes across cilia microtubule inner proteins with implications for human cilia function
Centrosomes and cilia are microtubule-based superstructures vital for cell division, signaling, and motility. The once thought hollow lumen of their microtubule core structures was recently found to hold a rich meshwork of microtubule inner proteins (MIPs). To address outstanding questions on how di...
ORGANISM(S): Homo sapiens (Human) 
2024-03-01 | PXD037582 | Pride
Cilia Centrosomes Proteomics Sequence alignment Microtubules Microtubule inner proteins Alphafold2 
ProteomicsProteomic profiling of centrosomes isolated from HAP1 cells
Centrosomes are cytoplasmic membraneless organelles that comprise a pair of centrioles, and a pericentriolar material. We developed a new centrosome affinity capture method termed CAPture that achieves high-coverage proteomes from 20-30 million cells. Here we present CAPture-MS data from HAP1 cells ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD043692 | Pride
Centrosome Human Hap1 
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