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ProteomicsMice with fibrinogen-induced arthritis (FIA)
This SuperSeries is composed of the following subset Series: GSE18023: Mice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies GSE18024: FIA plasma induces arthritis in naïve mice GSE18025: Fibrinogen-reactive T cells transfer disease to naïve mice Refer to individu...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18073 | biostudies-arrayexpress
ProteomicsMice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies
Synovial antigen arrays were probed with 1:150 dilutions of plasma derived from SJL mice immunized with fibrinogen emulsified in CFA or with CFA alone. Autoantibody binding was detected with a Cy3-conjugated goat-anti-mouse IgG/M secondary antibody. SAM was applied to identify antigens with statis...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18023 | biostudies-arrayexpress
ProteomicsFibrinogen-reactive T cells transfer disease to naïve mice
Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old naïve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic ...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18025 | biostudies-arrayexpress
ProteomicsOxidized fibrinogen HPLC-MS/MS
Fibrinogen is highly susceptible to oxidation compared to other plasma proteins. Fibrinogen oxidation damages its structure and affects the protein function. Fibrinogen was isolated from citrated human plasma by the modified cold ethanol precipitation technique. Oxidation of fibrinogen by ozone: a s...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD012046 | Pride
Oxidation Hplc-ms/ms Fibrinogen Oxidative post-translational modifications 
TranscriptomicsFibrinogen-induced differentiation of WT adult neural stem cells into astrocytes
Examination of gene expression during adult neural stem cell differentiation after 3 and 12 hours after fibrinogen treatment compared to control.
ORGANISM(S): Mus musculus 
2016-03-09 | E-MTAB-3013 | biostudies-arrayexpress
ProteomicsFIA plasma induces arthritis in naïve mice
Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrino...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18024 | biostudies-arrayexpress
ProteomicsFibrinogen function achieved through multiple covalent states
Disulfide bonds link pairs of cysteine amino acids and their formation is assumed to be complete in the mature, functional protein. We tested this assumption by quantifying the redox state of disulfide bonds in the thrombosis protein, fibrinogen. There is an extraordinary disulfide lability in fibri...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD018564 | Pride
Redox state Fibrinogen Cysteines Alpha2 macroglobulin 
ProteomicsMultiple disulfide-bonded states confer conformational diversity in fibrinogen
Disulfide bonds constrain the polypeptide backbone and reduce conformational variability in proteins. The blood clotting protein fibrinogen is constitutively produced as multiple partially disulfide-bonded states, suggesting that individual fibrinogen molecules have a variety of conformational forms...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD076459 | Pride
Human Fibrinogen Disulfide bonds 
ProteomicsHigh-Throughput Site-Specific N-Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation
Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations in its glycosylation have been implicated in various pathological conditions, yet its site-specific N-glycosylation profile remains largely unexplored in a clinical context. Here, we prese...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD058737 | Pride
Glycoproteomics Glycan Atrial fibrillation Fibrinogen High-throughput Site-specific N-glycosylation 
ModelsNaski1991 - alpha-Thrombin-catalyzed conversion of Fibrinogen
Mathematical model of blood coagulation factor alpha-thrombin and conversion of fibrinogen to fibrin with ATIII inhibition.
2018-08-21 | MODEL1808210002 | BioModels
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