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MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
MetabolomicsMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells...

2024-08-19 | MTBLS3973 | MetaboLights
ProteomicsG6PD K403 acetylation-dependent PTM
To identify acetylation-dependent posttranslational modifications (PTMs) of G6PD, site-specifically acetylated and Flag-tagged G6PD was expressed in HEK293T cells by genetically encoding the incorporation of acetylated lysine in response to an in-frame TAG stop codon. K403-acetylated G6PD (sample) a...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041775 | Pride
Human g6pd Ptm-dependent ptm Acetylation Phosphorylation 
ProteomicsNIK expression stimulated G6PD phosphorylation
Our findings establish NIK as a pivotal regulator of T cell metabolism in anti-tumor immunity and highlight a posttranslational mechanism of metabolic regulation involving the G6PD-NADPH redox system. CoIP assays revealed a strong physical interaction between NIK and G6PD in both T cells and transie...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD020943 | Pride
Nik G6pd Phosphoralytion 
ProteomicsDetermine G6PD/PHGDH deamidation in HepG2 cells with CAD depletion or in cell cycles
We report here that the trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase (CAD) activates the pentose phosphate pathway (PPP) and serine synthesis pathway (SSP) to promote de novo nucleotide synthesis via deamidation. Biochemical analyses show that CAD inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD055217 | Pride
Liver G6pd Phgdh Cad Deamidation 
ProteomicsSite-specifically acetylated G6PD
Site-specifically acetylated G6PD expressed in bacteria or cultured mammalian cells by genetically encoding the incorporation of acetylated lysine. Purified G6PD (expressed in E. coli) or immunopurified G6PD (expressed in HEK293T cells) were subjected to LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044906 | Pride
Metabolism Pentose phosphate pathway Lysine acetylation 
ProteomicsDeamidation sites of G6PD and PHGDH catalyzed by CAD
CAD interacts with and deamidates glucose-6-phosphate dehydrogenase (G6PD) and phosphoglycerate dehydrogenase (PHGDH), which are rate-limiting enzymes of the PPP and SSP, respectively. Here we identified G6PD and PHGDH deamidation sites by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD052165 | Pride
G6pd Phgdh Cad Deamidation 
ProteomicsEffects of G6PD deficiency on the phosphorylation and carbonylation of membrane protein complexes of human erythrocytes infected with Plasmodium falciparum
The ancestral parasite-host relationship associated with human malaria has driven the emergence of mutations in genes, such as erythrocyte glucose-6-phosphate dehydrogenase (G6PD), that confer resistance to lethal malaria and enhance human survival. Protein complexes in the erythrocyte membrane play...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2026-09-28 | PXD061301 | Pride
Carbonylation G6pd Phosphorylation Timstof Plasmodium falciparum exportome Blue native 
TranscriptomicsTranscriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells
Transcriptional profiling of in vitro differentiated CD36+ erythroid cells (from CD34+-Cord Blood (CB) in the presence and absence of NaBu (1mM /6hrs)
ORGANISM(S): Homo sapiens 
2014-04-28 | E-MTAB-2533 | biostudies-arrayexpress
ProteomicsIdentification of the potential regulators of G6PD activity in different cell cycle
Flag-G6PD was expressed in HeLa cells. Then the HeLa cells were synchronized with a double thymidine block procedure. Briefly, the exponentially growing HeLa cells were maintained with 2 mM thymidine for 18 h, followed by a release of 9 h in fresh medium, and then cells were re-cultured in 2 mM thym...
ORGANISM(S): Homo sapiens (Human) 
2023-05-18 | PXD033829 | Pride
G6pd Cell cycle 
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