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MetabolomicsMetabolic profiling reveals CAD as a central metabolic signaling node
LC MS metabolite profiling and carbon tracing were used to show that the pyrimidine synthesis enzyme CAD regulates glycolysis and branching into pentose phosphate and serine synthesis pathways to support cancer cell proliferation.
2026-02-03 | MTBLS13498 | MetaboLights
MetabolomicsPFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. To date, research on the direct interactions betwe...

2025-07-08 | MTBLS12688 | MetaboLights
ProteomicsIdentify HSV-1 proteins binding to CAD
To investigate the viral mechanism underlying HSV-1-mediated CAD activation, we sought to identify viral proteins that interact with CAD. HEK293T cells were transfected with FLAG-tagged CAD and subsequently infected with HSV-1. Proteins were immunoprecipitated using anti-FLAG or IgG antibodies and a...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD079633 | Pride
Hsv-1 Cad 
TranscriptomicsTranscriptional Profiling of CD133+ Cells in Coronary Artery Disease and Effects of Exercise on Gene Expression
Bone marrow-derived progenitor cells are under investigation for cardiovascular repair, but may be altered by disease. We identified 82 differentially expressed genes in CD133+ cells from patients with coronary artery disease (CAD) versus controls, of which 59 were found to be up-regulated and 23 do...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-18608 | biostudies-arrayexpress
ProteomicsDeamidation sites of G6PD and PHGDH catalyzed by CAD
CAD interacts with and deamidates glucose-6-phosphate dehydrogenase (G6PD) and phosphoglycerate dehydrogenase (PHGDH), which are rate-limiting enzymes of the PPP and SSP, respectively. Here we identified G6PD and PHGDH deamidation sites by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD052165 | Pride
G6pd Phgdh Cad Deamidation 
TranscriptomicsGenome Wide Linkage analysis of large family with coronary artery disease
We used linkage data from CAD family to search for the responsible variant in disease. we used illumina array for linkage analysis of CAD affected family.
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-42137 | biostudies-arrayexpress
ProteomicsDetermine G6PD/PHGDH deamidation in HepG2 cells with CAD depletion or in cell cycles
We report here that the trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase (CAD) activates the pentose phosphate pathway (PPP) and serine synthesis pathway (SSP) to promote de novo nucleotide synthesis via deamidation. Biochemical analyses show that CAD inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD055217 | Pride
Liver G6pd Phgdh Cad Deamidation 
TranscriptomicsCirculating Mononuclear Cell Transcriptomes in Patients with Atherosclerotic Coronary Artery Disease
Monocytes and T-cells play an important role in the development of atherosclerotic coronary artery disease (CAD). Differences in transcriptional activity of these cells might reflect the individual's atherosclerotic burden. Transcriptome analysis of circulating mononuclear cells from carefully match...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9820 | biostudies-arrayexpress
ProteomicsCAD-binding protein identification in HepG2 cells
To probe the possible mechanism by which CAD (trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase) promotescancer cell proliferation, we purified CAD via affinity chromatography from HepG2 cells stably expressing CAD-FLAG and identified its interacting protein...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD052153 | Pride
TranscriptomicsTranscription profiling of mouse CAD cells transfected with miR-124a-2 reveals the microRNA miR-124 Promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
Both microRNAs and alternative pre-mRNA splicing have been implicated in the development of the nervous system (NS), but functional interactions between these two pathways are poorly understood. We demonstrate that the neuron-specific microRNA miR-124a directly targets PTBP1/PTB/hnRNPI mRNA, which e...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8498 | biostudies-arrayexpress
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