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ProteomicsHuman immunoglobulin heavy gamma chain polymorphisms: molecular confirmation of proteomic assessment
Immunoglobulin G (IgG) proteins are known for the huge diversity of the variable domains of their heavy and light chains, aimed at protecting each individual against foreign antigens. The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant regions located on the Fc fra...
ORGANISM(S): Homo sapiens (Human) 
2017-03-13 | PXD005021 | Pride
Parasitic infection Allotype Imgt Mass spectrometry Igg Fc fragment Serological diagnosis Ighg Newborn Allele 
ProteomicsSite-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of individual healthy donors
The uploaded dateset corresponds to MS1 and MS2 spectra obtained for Fc gamma receptor IIIb isolated from neutrophils of individual healthy donors. They represent NA1/NA2, NA2/NA2, NA2/NA2 allotype respectively. Based on the data, the targeted analysis of the N-glycosylation has been performed for t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-05 | MSV000085913 | MassIVE
ProteomicsPrimary human natural killer cells retain proinflammatory IgG1 at the cell surface and express CD16a glycoforms with donor-dependent variability
Post-translational modification of NK cell CD16a and its IgG1 ligand
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-04 | MSV000083890 | MassIVE
ProteomicsHuman IgG subclasses differ in structural elements of their N-glycosylation
We tested tryptic plasma samples using HILIC-LC-MS/MS, which included mixed human plasma as well as plasma from two healthy individuals collected at three different time points, approximately one month apart. Our focus was on the glycan structure of the Fc domain of IGG subclasses. The results indic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-13 | MSV000095017 | MassIVE
TranscriptomicsGene expression analysis of gamma-M.tuberculosis-stimulated CD14hiCD16- and CD14loCD16+ monocytes
Current study will help us to elucidate the differential gene expression profiles of two different subsets of monocytes stimulated with gamma-M. tuberculosis CD14hiCD16- and CD14loCD16+ monocytes were isolated from human peripheral blood using magnetic beads for CD14 and CD16. 1.5 million cells were...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human peripheral blood gamma-delta T cells stimulated with HMB-PP or OKT-3
Here we compare the transcriptional profile of HMB-PP-stimulated versus OKT-3 stimulated human peripheral blood gamma-delta T cells. We show that HMB-PP faithfully reproduces the transcriptional events associated with bona fide activation through the T cell receptor (TCR).
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1601 | biostudies-arrayexpress
TranscriptomicsAnti-IFN antibody 16 array set
Timecourse experiment (0hr, 2hr,6hr and 21hr) where RNA was extracted from non-rested PBMCs which were exposed to 4 different conditions- nothing (mock), interferon (IFN)gamma, IFN gamma and a non-specific antibody and IFN gamma with purified patient antibody. The purified patient antibody is demons...
ORGANISM(S): Homo sapiens 
2005-09-17 | E-GEOD-3319 | biostudies-arrayexpress
ProteomicsOrigin of N-glycan site-specific heterogeneity glycopeptide analysis by LC-MSMS
LC-MS/MS analysis of glycopeptides of protein disulfide-isomerase (PDI1), etanercept, erythropoietin (EPO), low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), and spike glycoprotein (S) from wild type and Lec1 (GnT1-/-) HEK293 cells
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032149 | Pride
N-glycan heterogeneity glycopeptide lc-msms 
GenomicsSTAT1 transcription factor in Human HeLa S3
We report the results of chromatin immunoprecipitation following by high-thoughput tag sequencing (ChIP-Seq) using the GA II platform from Illumina for the human transcription factor STAT1 in HeLa S3 cells. The STAT1 ChIP was performed using HeLa S3 cells that are stimulated using gamma-interferon. ...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-12782 | biostudies-arrayexpress
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
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