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Analysis of human leukocyte antigen (HLA) allotype-specific response in abacavir-exposed keratinocyte
Immunoglobulin G (IgG) proteins are known for the huge diversity of the variable domains of their heavy and light chains, aimed at protecting each individual against foreign antigens. The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant regions located on the Fc fra...
ORGANISM(S): Homo sapiens (Human) 
2017-03-13 | PXD005021 | Pride
Abacavir, a nucleoside reverse-transcriptase inhibitor used for the treatment of human immunodeficiency virus (HIV) infection, develops hypersensitivity in patients carrying HLA-B*57:01 allele through drug antigen presentation. We found that abacavir exposure induced HLA allotype-specific innate imm...
ORGANISM(S): Mus musculus 
2018-03-01 | GSE110394 | GEO
Presentation of self- and foreign peptide antigens by human leukocyte antigen (HLA) complexes at the cell surface is a key process in our immune response. The alpha-chain, the part of the HLA class I complex that contains the peptide binding groove, is one of the most polymorphic proteins in the hum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD023684 | Pride
The extraocular muscles (EOM) are anatomically and physiologically distinct from other skeletal muscles. EOM are preferentially affected in mitochondrial myopathies, but spared in Duchenne's muscular dystrophy. The anatomical and pathophysiological properties of EOM have been attributed to their uni...
ORGANISM(S): Rattus norvegicus 
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