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ProteomicsRUNX1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of RUNX1 transcription factor in RPMI-8402 NKX2-1 +/+ and NKX2-1 -/-.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057654 | Pride
Human Nkx2-1 Runx1 Leukemia 
Proteomicsto screen the Treg inhibitor and investigate its mechanism in tumor
No Treg-specific therapeutics has been approved for clinical use. Our project aim to screen the Treg inhibitor and investigate its mechanism in tumor.
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD059236 | Pride
Human ip-ms runx1 
ProteomicsAnalysis of Amino Acid Variants in Malignant Melanoma Cells Resistant to BRAF inhibition
Analysis of patient-specific nucleotide variants is a cornerstone of personalised medicine. Although only 2% of the genomic sequence is protein-coding, mutations occurring in these regions have the potential to influence protein structure and may have severe impact on disease aetiology. Of special i...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD018305 | Pride
Nucleotide sequencing Melanoma Mass spectrometry Proteogenomics Cancer Brafi resistance Phosphorylation 
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Recent data have shown that Hypermethylated in cancer 1 (HIC1) is an important contributor to iTreg cell development and function. Using affinity-purification and tandem mass spectrometry we systematically characterized the HIC-1 interactome in human iTreg cells. On the basis of these data, we have ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD039337 | Pride
Hic1  interactome  immunoprecipitation  proteomics  foxp3  protein complex  runx1  regulatory t cells  t cell differentiation  tgf-β  treg  itreg. 
ProteomicsNKX2-1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of NKX2-1 transcription factor in RPMI-8402 NKX2-1 +/+, using NKX2-1 -/- as negative control.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057622 | Pride
Human Nkx2-1 Leukemia 
ProteomicsThe GF-NEO Discovery Platform: A Systems-Level Approach to Analyzing and Validating Fusion Neoantigens in Pediatric Cancer
Gene fusions (GFs) are critical events in pediatric oncology, often serving as oncogenic drivers. However, fusion proteins and their derived neoantigens (GF-NEOs) remain underexplored for targeted immunotherapy. We developed ProteoFusioNEO, a computational tool for in silico translation of transcrip...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD063253 | Pride
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