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MetabolomicsChronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

The study investigates the effects of 6PPDQ on male fertility in adult mice. The findings of this study are essential as the effects of low-dose environmental factors of 6PPDQ on adult male infertility are unclear, with the increasing in male infertility. The results suggest that 6PPDQ adversely ...

2025-07-14 | MTBLS9432 | MetaboLights
MetabolomicsFunctional Remodeling of the Gut Microbiome and Metabolome in Primary Idiopathic Male Infertility

Abstract

Background: Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes, yet microbiome-associated fun...

2026-04-07 | MTBLS13886 | MetaboLights
TranscriptomicsEffect of miR-106b~25 in mouse spermatogenesis and male fertility
We investigated the miRNA cluster miR-106b~25 as potential candidate causing male infertility. We analized single and double KO mice. Single KO show derregulation of multiple molecular pathways and disrupted early spermatogenesys, but retain fertility. Double KO show severely disrupted testicular hi...
ORGANISM(S): Mus musculus 
2020-11-06 | E-MTAB-8964 | biostudies-arrayexpress
GenomicsDirect but No Transgenerational Effects of Decitabine and Vorinostat on Male Fertility
Epigenetic drugs actively altering the epigenome of tumours have been developed for use in anti-cancer therapies. However, these drugs could potentially also affect the DNA methylome of spermatozoa that seems to be essential for male fertility. Here, we analysed possible direct and transgenerational...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-59575 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3 wild-type and 3 Crtc1 knockouts reveals the Creb1 coactivator Crtc1 is required for energy balance and fertility
The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that trigger the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3 signaling promotes obesity in mice, other features of Lepr function, such as...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-12209 | biostudies-arrayexpress
ProteomicsComprehensive Proteomics Analysis of Bovine Sperm Head Plasma Membrane Associated with Fertility
Bull fertility impacts herd fertility, but accurately predicting male fertility from sperm characteristics is difficult once extremes are removed. The objectives of this study are identification, relative quantification, and comparison of sperm head plasma membrane (HPM) proteomics in bulls of diffe...
ORGANISM(S): Bos taurus (Bovine) 
2026-06-08 | PXD047294 | Pride
Fertility biomarkers Proteomics analysis Bull fertility Sperm head plasma membrane 
TranscriptomicsTranscription profiling of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis in highly enriched cell populations
We report a comprehensive large-scale expression profiling analysis of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis using High Density Oligonucleotide Microarrays and highly enriched cell populations. Among 11955 rat loci investigated, 1268 were identified as differ...
ORGANISM(S): Rattus norvegicus 
2004-03-01 | E-MEXP-31 | biostudies-arrayexpress
TranscriptomicsArray-based DNA methylation profiling in male infertility reveals allele-specific DNA methylation in PIWIL1 and PIWIL2
Array-based DNA methylation profiling in peripheral blood leukocytes of 30 infertile men with impaired spermatogenesis as compared to 10 fertile men using the Illumina Infinium HumanMethylation 450k Bead Chip reveald 471 CpG sites (287 genes) to be differentially methylated between both groups. Thes...
ORGANISM(S): Homo sapiens 
2014-02-16 | E-GEOD-51245 | biostudies-arrayexpress
ProteomicsDiscontinuation of chronic delta-9-tetrahydrocannabinol diminishes impact on male fertility and the sperm epigenome in rhesus macaques
Cannabis is commonly used amongst reproductive age males. Our group and others have shown that chronic delta-9-tetrahydrocannabinol (THC) use adversely impacts male fertility, but less is known about the potential reversibility of these changes. Our study’s objective was to determine if THC disconti...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2023-05-18 | PXD039802 | Pride
Cannabis Quantitative proteomics Male fertility Seminal fluid Rhesus macaque Mass spectrometry Isobaric labeling 
ProteomicsTargeted validation of significantly altered semen proteins in COVID-19 patients
The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long...
ORGANISM(S): Homo Sapiens 
2022-06-26 | PXD026849 | panorama
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