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ProteomicsTemporal Expression Profiling of Plasma Proteins in Type 1 Diabetes Progression
A longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n = 11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy control...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084341 | MassIVE
UnknownDetermining Plasma Protein Variation Parameters as a Prerequisite for Biomarker Studies-A TMT-Based LC-MSMS Proteome Investigation.
Not available
S-EPMC8707687 | biostudies-literature
ProteomicsIn-depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-glycoproteomic Impact of an Amish Enriched Cardioprotective Variant in B4GALT1
Proteome and N-glycoproteome in human plasma were analyzed and compared between B4GALT1 WT and N352S genotypes. The results showed that N352S significantly decreased galactosylation for a wide range of proteins, especially apoB and fibrinogen, which may be associated with the decreased LDL-c level o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-29 | MSV000090976 | MassIVE
ProteomicsLC-MSMS analysis of plasma from multiple sclerosis-affected patients
Multiple sclerosis (MS) is a common autoimmune and degenerative disorder caused by chronic inflammatory reactions in the central nervous system. However, little is known about the changes of plasma proteomic profiles in Chinese patients with MS (CpwMS), and potential molecular networks that underlie...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD040101 | Pride
Proteomic profile  lc-msms  differentially expressed protein  plasma  multiple sclerosis  potential biomarker 
ProteomicsAlterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia
For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such...
ORGANISM(S): Homo sapiens (Human) 
2019-03-27 | PXD012221 | Pride
Proteomics  high altitude  hypobaric hypoxia  complement and coagulation cascades  antioxidant  glycolysis. 
ProteomicsA TMT- based comparative quantitative proteomics analysis was used to reveal the changes of plasma proteomics profiles between longevity subjects and non-longevity area participants in order to identify plasma proteins associated with glucose metabolism in longevity population
High blood glucose level is one of the main characteristics of diabetes mellitus (DM). It is speculated that longevity families may have certain advantages in blood glucose regulation. But till now, limited information on these items is reported. In this study, a TMT- based comparative quantitative ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032932 | Pride
Human plasma lc/msms tmt 
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
ProteomicsExercise plasma dampens brain inflammation via clusterin and boosts memory
Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects....
ORGANISM(S): Mus musculus (Mouse) 
2021-12-22 | PXD022262 | Pride
Lc-msms Mouse Plasma 
ProteomicsHuman Neutrophils in Pulmonary Arterial Hypertension by LC-MSMS
Neutrophil elastase (NE) is implicated in pulmonary arterial hypertension (PAH) but the role of neutrophils in the pathogenesis of PAH is unclear. Here we show that neutrophils from PAH vs. control subjects produce and release increased NE associated with enhanced extracellular trap formation. PAH n...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD023134 | Pride
Lc-msms Pulmonary arterial hypertension Neutrophils 
ProteomicsComparative proteomics of liver and plasma on the CDAA rat NASH model
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-28 | PXD014751 | Pride
Lc-msms Plasma Han wistar rat Liver 
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