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TranscriptomicsDifferential gene expression in Aspergillus fumigatus induced by human platelets in vitro
Differentially expressed genes in Aspergillus fumigatus following exposure to human platelets in a timeseries experiment (15min, 30min, 1h, 3h) compared to untreated fungi as reference using customized Geniom (R) Biochips (febit) comprising 9500 genes (14051 features) were studied in order to gain a...
ORGANISM(S): Aspergillus fumigatus Af293 
2015-01-22 | E-MTAB-3024 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human platelets from patients with essential thrombocythemia
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quant...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-2006 | biostudies-arrayexpress
TranscriptomicsThrombocythemic Platelets microRNA Profiling
Post-transcriptional and translational controls mediated by microRNAs (miRNA) regulate diverse biological processes and disease. We systematically dissected regulatory effects of miRNAs relevant to megakaryocytopoiesis and platelet biology by analyzing expression patterns in 79 subjects with thromb...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-39046 | biostudies-arrayexpress
TranscriptomicsRNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass and molecular pathway cancer diagnostics
We report RNA-sequencing data of 283 blood platelet samples, including 228 tumor-educated platelet (TEP) samples collected from patients with six different malignant tumors (non-small cell lung cancer, colorectal cancer, pancreatic cancer, glioblastoma, breast cancer and hepatobiliary carcinomas). I...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-68086 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile of platelets in sickle cell disease
Circulating platelets from Sickle cell disease (SCD) patients express distinct gene expression patterns that regulate function. The objective of this study is to identify a role of post-transcriptional regulation of the platelet transcriptional signaling by microRNAs. Comparison of microRNA expressi...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41574 | biostudies-arrayexpress
MetabolomicsA metabolomic study of urinary changes in type 2 diabetes in human compared to the control group
Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in ...
2012-02-14 | MTBLS1 | MetaboLights
TranscriptomicsPlatelet microRNA-mRNA Co-Expression Profiles Correlate with Platelet Reactivity
MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that...
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-27917 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human ovarian cancer cell lines grown in the presence and absence of washed human platelets
The objective of the study was to determine the influence of platelets on the transcriptome profile of ovarian cancer cells Ovarian cancer cell lines (SKOV3 and 59M) were co-cultured with human washed platelets for 24 hours prior to RNA extraction. These samples were then analysed on affymetrix huma...
ORGANISM(S): Homo sapiens 
2022-07-01 | E-MTAB-9673 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human highly purified platelets from normal individuals
Transcription profiling of highly purified platelets from normal individuals
ORGANISM(S): Homo sapiens 
2010-09-30 | E-MTAB-374 | biostudies-arrayexpress
TranscriptomicsIGR_Raslova_LMMC
Characterization of genetic alterations in monocoyte lineage (CD14+ cells) of two CMML (Chronicle Myelo-Monocytic Leukemia) patients. Previously we have shown that RUNX1 downregulates MYH10 expression in megacaryocyte lineage leading in MYH10 overexpression in platelets of patients wiht RUNX1 geneti...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-MTAB-1121 | biostudies-arrayexpress
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