Sort   by:  
 Page size 
MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsStirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells (hPSCs)
Not available
ORGANISM(S): Homo sapiens 
ST001377 | MetabolomicsWorkbench
MetabolomicsMetabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors
Not available
ORGANISM(S): Homo sapiens 
ST002055 | MetabolomicsWorkbench
MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
ProteomicsEndogenous THBS1 is C-mannosylated by human induced pluripotent stem cells.
We used a human thrombospondin-1 (THBS1) fragment comprising thrombospondin type 1 repeats (TSRs) 1 to 3, which was recombinantly expressed in HEK 293T cells and digested with AspN to determine chromatographic retention times and to optimise MS parameters. We detected two peptides from TSR2 and TSR3...
ORGANISM(S): Homo Sapiens 
2021-05-12 | PXD024117 | panorama
ProteomicsProteome analysis of brainstem organoids from human pluripotent stem cells
Brain organoids derived from human pluripotent stem cells recapitulate the course of human brain development. We applied proteomic analysis to human brainstem organoids which were developed by a novel method.
ORGANISM(S): Homo Sapiens (human) 
2020-05-01 | PXD016807 | JPOST Repository
TranscriptomicsHuman oocytes reprogram adult somatic cells to pluripotent stem cells [Illumina]
The stem cell lines were generated according to the principle described in Noggle et al., Nature 2011, Oct 5;478(7367):70-5. doi: 10.1038/nature10397. Title: Human oocytes reprogram somatic cells to a pluripotent state. Abstract: The exchange of the oocyte's genome with the genome of a somatic cel...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-60360 | biostudies-arrayexpress
TranscriptomicsscRNA-seq to investigate endoderm differentiation from induced human pluripotent stem cells
Single-cell RNA-seq (scRNA-seq) on nocodazole and DMSO treated cells before and after differentiation into endoderm. hPSC colonies were treated with DMSO or 100ng/ml nocodazole for 16 hours and induced to differentiate into definitive endoderm for three days. Single cells were subsequently collected...
ORGANISM(S): Homo sapiens 
2019-02-09 | E-MTAB-7008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human induced pluripotent stem cells signature and memory retention
Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and...
ORGANISM(S): Homo sapiens 
2009-12-19 | E-GEOD-18618 | biostudies-arrayexpress
Sort   by:  
 Page size