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ProteomicsThe exercise-regulated skeletal muscle phosphoproteome
Four healthy male volunteers (age: 24 - 27; BMI: 24.2 - 25.9 kg/m2) underwent a single bout of high-intensity bicycle exercise reaching a VO2 max approximately 95% with blood samples and muscle biopsies taken immediately pre- and post-exercise. Subjects reached 95% VO2 max in approximately 9 to 12 m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080777 | MassIVE
ProteomicsAdaptation-dependent alterations in the human skeletal muscle proteome and phosphoproteome of human skeletal muscle in response to damaging resistance exercise
Resistance exercise (RE) enhances strength, muscle mass, and overall health. Intense RE also triggers rapid muscle damage that is efficiently restored through proteostatic mechanisms in healthy individuals. However, the specific factors and signalling processes active at sites of damage remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD044976 | Pride
Resistance exercise Proteomics Adaptation Fractionation Human muscle Phosphoproteomics Deadaptation 
ProteomicsPhosphoproteomic analysis of three exercise modalities in human skeletal muscle
To characterize phosphorylation-based signaling events across different exercise modalities we subjected eight healthy young men (age, 26.3±1.3 years; BMI, 23.5±0.7 kg/m2; maximal oxygen uptake (VO2 max), 42.6±1.5 ml/kg/min) that did not perform regular physical activity apart from local bicycling t...
ORGANISM(S): Homo sapiens (Human) 
2022-07-18 | PXD031049 | Pride
Skeletal muscle Phosphoproteomics Exericse 
ProteomicsPersonalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action
Insulin resistance, the defective regulation of glucose metabolism by insulin, increases the risk of type 2 diabetes and cardiovascular disease. It is not yet known how insulin resistance remodels signalling networks in human tissues. Here, we define the signalling architecture of insulin resistance...
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD032948 | Pride
Insulin resistance Proteomics Post-translational modification Mass spectrometry Exercise Skeletal muscle Signal transduction Phosphorylation Phosphoproteomics Human 
ProteomicsThe exercise-regulated skeletal muscle phosphoproteome
Four healthy male volunteers (age: 24 - 27; BMI: 24.2 - 25.9 kg/m2) underwent a single bout of high-intensity bicycle exercise reaching a VO2 max approximately 95% with blood samples and muscle biopsies taken immediately pre- and post-exercise. Subjects reached 95% VO2 max in approximately 9 to 12 m...
ORGANISM(S): Homo sapiens (Human) 
2016-06-29 | PXD001543 | Pride
Skeletal muscle Phosphoproteomics Exericse 
ProteomicsInsulin and Exercise-induced Phosphoproteomics of Human Skeletal Muscle Identify REPS1 as a New Regulator of Muscle Glucose Uptake
Skeletal muscle regulates glucose uptake in response to insulin and exercise which is critical for maintaining metabolic health. We conducted a comprehensive phosphoproteomic analysis of skeletal muscle from healthy people in response to an acute bout of exercise or insulin stimulation by a hyperins...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-06 | PXD046755 | Pride
Skeletal muscle signaling Glucose metabolism Phosphoproteomics 
ProteomicsPhosphoproteomics of High Intensity Interval Training
Ten healthy male participants were recruited and successfully completed all preliminary testing and the two exercise bouts (Figure 1A). This randomized crossover design permitted signaling responses to workload- and duration-matched HIIT and MICT exercise to be mapped and interrogated within the sam...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD053295 | Pride
Human skeletal muscle exercise phosphoproteomics 
ProteomicsPhosphoproteomic screening of exercise-like treatments reveals drug interactions regulating protein secretion
Exercise triggers skeletal muscle signalling pathways that modulate the release of circulating factors to cause systemic health benefits. Understanding these mechanisms could lead to better strategies for treating cardiometabolic diseases. We previously showed that acute exercise induces >1000 chang...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-09-26 | PXD014322 | Pride
Phosphoproteomics Exercise Myotubes 
ProteomicsTemporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise
The skeletal muscle interstitial space is the extracellular region around myofibres and mediates crosstalk between resident cell types. We applied a proteomic workflow to characterise the human skeletal muscle interstitial fluid proteome at rest and in response to exercise. Following exhaustive exer...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-01-16 | PXD058818 | Pride
Secretomics Exercise Interstitial fluid Skeletal muscle 
ProteomicsHyperammonemia-dependent and independent skeletal muscle phosphoproteomic responses during exercise
Phosphorylation of skeletal muscle proteins mediates cellular signaling and adaptive responses to exercise. Bioinformatic and machine learning approaches identified preclinical models that recapitulate human exercise responses. Feature selection showed that muscles from treadmill running mice and ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-25 | PXD031372 | Pride
Mass spectrometry Hyperammonemia Skeletal muscle Phosphoproteomics 
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