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ProteomicsCalcific hVIC niclosamide treatment
Niclosamide has emerged as a promising drug for cardiac valve calcification treatment. Previous study suggested niclosamide's protective effects against vascular smooth muscle cell calcification. Yet, its impact on human VICs remained unexplored. In this study, we performed global and phospho-proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD047708 | Pride
Cavd Proteomics. calcification Hvic Niclosamide 
ProteomicsRNF130 induces aortic valve calcification in HVIC
The study of the RNF130 gene induces valve calcification in HVIC, which correlates the proteome
ORGANISM(S): Homo Sapiens 
PXD066642 |
UnknownAmino acid 138 in the HA of a H3N2 subtype influenza A virus increases affinity for the lower respiratory tract and alveolar macrophages in pigs.
Not available
S-EPMC10906893 | biostudies-literature
UnknownPALMD regulates aortic valve calcification via altered glycolysis and NF-κB-mediated inflammation.
Not available
S-EPMC9065630 | biostudies-literature
UnknownAnthraquinone Emodin Inhibits Tumor Necrosis Factor Alpha-Induced Calcification of Human Aortic Valve Interstitial Cells via the NF-κB Pathway.
Not available
S-EPMC6252319 | biostudies-literature
UnknownHsa_circ_0003748 promotes disease progression in rheumatic valvular heart disease by sponging miR-577.
Not available
S-EPMC9169177 | biostudies-literature
UnknownShape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture.
Not available
S-EPMC6178984 | biostudies-literature
TranscriptomicsCirculating monocytes from patients promote calcific aortic valve disease development
Calcific Aortic Valve Disease (CAVD) is the most frequent valvular heart disease in developed countries. It is characterized by a progressive calcification of aortic valve leaflets mediated by myeloid cells, such as monocytes and macrophages. However, the molecular mechanisms involved in their recru...
ORGANISM(S): Homo sapiens 
2025-02-24 | GSE290104 | GEO
TranscriptomicsOscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RNA-Seq]
Calcific aortic valve disease (CAVD) involves pathological crosstalk between human valvular endothelial cells (hVECs) and interstitial cells (hVICs), yet the role of this communication in pathogenesis remains poorly defined. Here, we identify a novel extracellular vesicle-derived circRNA, CircILRUN,...
ORGANISM(S): Homo sapiens 
2025-08-26 | GSE306211 | GEO
OtherOscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RIP-seq]
Calcific aortic valve disease (CAVD) involves pathological crosstalk between human valvular endothelial cells (hVECs) and interstitial cells (hVICs), yet the role of this communication in pathogenesis remains poorly defined. Here, we identify a novel extracellular vesicle-derived circRNA, CircILRUN,...
ORGANISM(S): Homo sapiens 
2025-09-30 | GSE306740 | GEO
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