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TranscriptomicsGrowth inhibition of ovarian tumor-initiating cells by niclosamide
The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show ste...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36259 | biostudies-arrayexpress
TranscriptomicsEffect of niclosamide on gene expression in the snail Biomphalaria glabrata
In order to understanding the mechanisms of action of niclosamide, the active ingredient in the molluscicides, we used a Biomphalaria glabrata oligonucleotide microarray to investigate the effect of three sublethal exposures to niclosamide on the transcriptional responses of the snail B. glabrata re...
ORGANISM(S): Biomphalaria glabrata 
2015-07-23 | E-GEOD-71223 | biostudies-arrayexpress
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
ProteomicsCalcific hVIC niclosamide treatment
Niclosamide has emerged as a promising drug for cardiac valve calcification treatment. Previous study suggested niclosamide's protective effects against vascular smooth muscle cell calcification. Yet, its impact on human VICs remained unexplored. In this study, we performed global and phospho-proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD047708 | Pride
Cavd Proteomics. calcification Hvic Niclosamide 
GenomicsRepurposing niclosamide in mouse models of amyotrophic lateral sclerosis
Repurposing niclosamide in mouse models of amyotrophic lateral sclerosis
PRJNA1047112 | ENA
ProteomicsA Gene Expression-based Strategy Identifies the Anthelminthic Drug Niclosamide for High-risk Neuroblastoma Therapy
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with diverse clinical behaviors. Even with multimodal therapies, high-risk neuroblastoma has an unfavorable outcome irrespective of MYCN amplification, a well-established oncogenic driver in neuroblastoma pathogenesis, a...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD010745 | Pride
Neuroblastoma  mycn  recurrent drug−transcript relationships  niclosamide  lc-ms/ms  metabolism 
GenomicsThe efficacy of niclosamide on the intra-abdominal inflammatory environment in endometriosis
The efficacy of niclosamide on the intra-abdominal inflammatory environment in endometriosis
PRJNA612816 | ENA
ClinicalNiclosamide for Familial Adenomatous Polyposis
Familial adenomatous polyposis (FAP) leads to adenomas and eventual adenocarcinomas in colon and less frequently, duodenum. Chemopreventive strategies have been studied in FAP patients to delay the development of adenomas and cancers. The non-steroidal anti-inflammatory drugs (NSAIDs) and selective ...
2332203 | ecrin-mdr-crc
TranscriptomicsGrowth inhibition of ovarian tumor-initiating cells by niclosamide
The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show ste...
ORGANISM(S): Homo sapiens 
2012-08-06 | GSE36259 | GEO
GenomicsA STAT3 inhibitor Niclosamide Inhibits PRRSV replication
A STAT3 inhibitor Niclosamide Inhibits PRRSV replication
PRJNA1430589 | ENA
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