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ProteomicstRNA binding to KEOPS human protein complex
N6-theronylcarbomyl adenosine (t6A) is a universal tRNA posttranscriptional modification that promotes translation fidelity and is therefore required for the fitness of virtually all living cells. Kae1, the t6A modifying enzyme in eukaryotes and archea, resides within the KEOPS complex with three au...
ORGANISM(S): Homo sapiens (Human) 
2020-12-11 | PXD018007 | Pride
Trna Keops Hx-ms 
ProteomicsImproving spectral validation rates in hydrogen-deuterium exchange data analysis.
HX-MS data generated to support the testing and development of the HX data analysis applications in Mass Spec Studio.
ORGANISM(S): Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2021-02-22 | PXD022831 | Pride
Hx-deal Hdx-ms Mass-spec studio Proteasome Hx-pipe Eg5 
ProteomicsIntegrative Structural Model of DNA-PK Synapsis
In non-homologous end joining repair of DNA double strand breaks, DNA dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/80 binds the free DNA ends forming the holoenzyme DNA-PK. DNA-PK synapses across the break to tether the broken ends in the initial long range synaptic complex. We gen...
ORGANISM(S): Homo sapiens (Human) 
2021-01-20 | PXD017931 | Pride
Dna-pk Hydrogen deuterium exchange Crosslinking 
UnknownAssociation of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1.
Not available
S-EPMC4577885 | biostudies-literature
UnknownComputational analysis of antibody dynamics identifies recent HIV-1 infection.
Not available
S-EPMC5752300 | biostudies-literature
TranscriptomicsMicroRNA expression in rat soleus muscle during atrophy induced by hindlimb suspension
The objective of the study was to identify microRNAs expressed in the rat soleus muscle and determine if their expression was changed in response to hindlimb suspension. The microRNA expression profile (Sanger miRBase 9.0) of the rat soleus muscle was determined in the following three groups: contro...
ORGANISM(S): Rattus norvegicus 
2009-08-25 | E-GEOD-17776 | biostudies-arrayexpress
TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
TranscriptomicsMicroarrays reveal oocyte lipid storage droplet gene as key factor in reproductive dysfunction of captive-reared P. monodon
Background: Aquaculture of the black tiger prawn Penaeus monodon remains severely constrained by an almost total dependence on wild-caught broodstock. Reliance on wild-caught broodstock stems, for the most part, from reduced reproductive potential of captive-reared females. Reproductive performance ...
ORGANISM(S): Penaeus monodon 
2011-09-01 | E-GEOD-31862 | biostudies-arrayexpress
TranscriptomicsInvestigating H. Influenzae Species Diversity by Comparative Genomic Hybridization
Haemophilus influenzae(Hi) is a gram-negative rod shaped bacterium that lives symbiotically in the upper respiratory tract of humans. Capsulated Hi, as well as non-capsulated strains are known to cause a number of significant infections. Recognizing and understanding the links between the phenotypic...
ORGANISM(S): Haemophilus influenzae 
2010-10-08 | E-GEOD-8300 | biostudies-arrayexpress
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