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ProteomicsStrategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice
Hybrid insulin peptides (HIPs) form in pancreatic beta cells through the covalent cross-linking of proinsulin peptides with various beta cell peptides, creating unique amino acid sequences not encoded in the genome. HIPs have been confidently identified in both human and mouse islets by mass spectro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-22 | PXD063329 | Pride
Nod Hybrid insulin peptides Insulin Type 1 diabetes 
ProteomicsIdentification of HIPs in the islets of mice and non-diabetic human donors
Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-07 | PXD011606 | Pride
Hybrid insulin peptides (hips) Pancreatic islets 
ProteomicsReanalysis of NOD mouse insulin granule and secreted peptidome data
Data from a previous publication from our lab (Nature 2018 Aug; 560 (7716): 107-111) were reanalyzed by performing a multiround search against a Uniprot-Mouse database followed by an in silico database of hybrid insulin peptides.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-11 | PXD015726 | Pride
Mouse Hybrid insulin peptides Type 1 diabetes 
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
UnknownT-cell responses to hybrid insulin peptides prior to type 1 diabetes development.
Not available
S-EPMC8017940 | biostudies-literature
ProteomicsProteomics of Enriched Insulin Secretory Granules Fractionated by Size Exclusion Chromotography
Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs, which have been confidently identified in pancreatic islets by mass spectrometry, are targeted by CD4 T cells in subjects with Type 1 Diabetes (T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD032664 | Pride
Beta cell Proteins Insulin secretory granule Proteases 
UnknownIdentification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry.
Not available
S-EPMC7597855 | biostudies-literature
UnknownT cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8.
Not available
S-EPMC8387461 | biostudies-literature
UnknownInsulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes.
Not available
S-EPMC9399855 | biostudies-literature
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