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ProteomicsIdentification of HIPs in the islets of mice and non-diabetic human donors
Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-07 | PXD011606 | Pride
Hybrid insulin peptides (hips) Pancreatic islets 
ProteomicsStrategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice
Hybrid insulin peptides (HIPs) form in pancreatic beta cells through the covalent cross-linking of proinsulin peptides with various beta cell peptides, creating unique amino acid sequences not encoded in the genome. HIPs have been confidently identified in both human and mouse islets by mass spectro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-22 | PXD063329 | Pride
Nod Hybrid insulin peptides Insulin Type 1 diabetes 
UnknownIdentification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry.
Not available
S-EPMC7597855 | biostudies-literature
ProteomicsProteomics of Enriched Insulin Secretory Granules Fractionated by Size Exclusion Chromotography
Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs, which have been confidently identified in pancreatic islets by mass spectrometry, are targeted by CD4 T cells in subjects with Type 1 Diabetes (T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD032664 | Pride
Beta cell Proteins Insulin secretory granule Proteases 
ProteomicsNOD Mouse Islet Peptide Content Identification
Beta-cells produce hybrid insulin peptides (HIPs) by linking insulin fragments to other peptides through peptide bonds. HIPs have unique amino acid sequences and are targeted by autoreactive T cells in type 1 diabetes (T1D). Individuals with recent-onset T1D have significantly higher levels of HIP-r...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD041616 | Pride
Hips Nod mouse Islet cells Peptides Lc-msms 
UnknownT-cell responses to hybrid insulin peptides prior to type 1 diabetes development.
Not available
S-EPMC8017940 | biostudies-literature
UnknownHybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes.
Not available
S-EPMC6702640 | biostudies-literature
UnknownInsulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes.
Not available
S-EPMC9399855 | biostudies-literature
UnknownCathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes.
Not available
S-EPMC9750942 | biostudies-literature
UnknownT cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8.
Not available
S-EPMC8387461 | biostudies-literature
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