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ProteomicsIdentification of RUNX1 binding proteins in control and entinostate treated mouse leukemia cells
Runt-related Transcription Factor 1 (RUNX1) is essential for definitive hematopoiesis and is among the most frequently mutated genes in leukemia. Previous work from our lab demonstrated that Histone Deacetylase 1 (HDAC1), a known RUNX1 partner, is unexpectedly required for active transcription sugge...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD068027 | Pride
Hdac1 Leukemia Ptbp1 Runx1 Aml 
ProteomicsPAMD-Ch17, a Polymeric Analog of Plerixafor, Induces Mitochondrial Dysfunction in T-ALL Cells Independent of CXCR4
PAMD-Ch17 is a polymer composed of the CXCR4 inhibitor AMD3100/Plerixafor with a cholesterol modification. In previous work, we showed that PAMD-Ch17, but not AMD3100, induces cell death and differentiation in mouse Acute Myeloid Leukemia cells. To investigate the mechanism of PAMD-Ch17’s novel anti...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD066096 | Pride
Polymeric drugs Amd3100 Cxcr4 Leukemia T-all 
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