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MetabolomicsSphingomyelin depletion inhibits CXCR4 dynamics and CXCL12-mediated directed cell migration in human T cells
Not available
ORGANISM(S): Homo sapiens 
ST002150 | MetabolomicsWorkbench
TranscriptomicsGene expression pattern in CXCR4+ and CXCR4- subpopulation of breast cancer cells
The goal of this study was to identify signalling molecules downstream of CXCR4 in breast cancer cells. For this purpose, we sorted CXCR4-positive and CXCR4-negative cells from MDA-MB-231 breast cancer cell line by flow cytometry and performed microarrays analysis. Three sets of samples, each in qua...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-15893 | biostudies-arrayexpress
TranscriptomicsExpression data from CXCR4+/FLK1+ and CXCR4-/FLK1- cells isolated by flow cytometry from Day 5 embryoid bodies
A dual biomarker signature extracted a stage-specific cytotype according to cell surface expression of CXCR4/FLK-1 after 5 days of spontaneous differentiation from pluripotent stem cells. Genome-wide microarray analysis revealed a high degree of similarity between CXCR4+/FLK-1+ and CXCR4-/FLK-1- sub...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-20841 | biostudies-arrayexpress
TranscriptomicsGene expression profile of C1013G/CXCR4 mutated WM cells
C1013G/CXCR4 variant has been inserted into BCWM.1 cells, and gene expression profile has been performed on the mutated cells and on the parental cells. Affimetrix Human Genome U133_Plus2.0 array We used microarrays to dissect the possible changes occurring at mRNA level in mutated cells versus the ...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-50683 | biostudies-arrayexpress
ProteomicsLC-MS characterization of anti-PD-L1 and CXCR4 bispecific nanobodies
Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a nanobody molecule with bi-targeting on PD-L1 and CXCR4, as both targets are overexpressed i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037102 | Pride
Nanobody Lc-ms Bispecific Protein Complete mw 
TranscriptomicsCXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AHR signaling
Targeting the estrogen signaling pathway has proved to be of great value in the treatment of human breast cancer. Tamoxifen, a selective estrogen receptor modulator (SERM), is the most widely used antiestrogen. However, only 40-50% of patients with estrogen receptor (ER) positive breast cancer benef...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-31831 | biostudies-arrayexpress
TranscriptomicsCXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by infiltration of the bone marrow and other sites with transformed T cell progenitors. The role of tissue microenvironments in the pathogenesis of T-ALL or any other type of acute leukemia is little ...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-60367 | biostudies-arrayexpress
ProteomicsPhysical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential
Chemokine receptor 4 (CXCR4) is a member of the chemokine receptor family that is overexpressed in various cancer types and has been involved in cancer progression and metastasis. In light of recent findings suggesting that intracellular CXCR4 rather than CXCL12-CXCR4-operated signaling promotes can...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD054221 | Pride
G protein-coupled receptor Ap-ms Cxcr4 Chemokine Signalling Trafficking Ephrin Interactome 
TranscriptomicsGene expression profiling after RNA interference of CXCR4 in human ovarian cancer cell line IGROV-1.
In the past three years the role of inflammatory cytokines and chemokines in tumour promotion and progression has been intensively studied. The chemokine receptor CXCR4 and its ligand CXCL12 are commonly expressed in malignant cells from primary tumours, metastases and also in malignant cell lines. ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13763 | biostudies-arrayexpress
TranscriptomicsThe disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1M-NM-1-induced gene expression, invasion and chemosensitivity of colon cancer
In colorectal cancer, increased expression of the CXC chemokine receptor 4 (CXCR4) has been shown to provoke metastatic disease due to the interaction with its ligand stromal cell-derived factor 1 (SDF-1). Recently, a second SDF-1 receptor, CXCR7, was found to enhance tumor growth in solid tumors. A...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-40017 | biostudies-arrayexpress
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