Sort   by:  
 Page size 
ProteomicsHuman alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells
Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells (iAT2s) have rapidly contributed to our understanding of AT2 function and disease. However, as iAT2s are primarily cultured in three-dimensional (3D) Matrigel, a matrix derived from cancerous mouse tissue, it i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-10 | MSV000091470 | MassIVE
TranscriptomicsSingle cell RNA-seq of hiPSC-derived kidney organoids differentiated within self-assembling peptide hydrogels and the animal-derived matrix Matrigel
scRNA-seq was used to characterise hiPSC-derived kidney organoids differentiated within fully synthetic self-assembling peptide hydrogels of variable mechanical strengths and compare these to organoids differentiated within the animal-derived matrix, Matrigel. Organoids were matured in the respectiv...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-11149 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of myeloid cell lines in Gelatin Methacrylate Hydrogels
Recapitulate the myeloid sarcoma gene expression using Gelma hydrogels in leukemic cell lines RNA-seq was performed onleukemic cell lines K562, Molm-13, PL-21, OCI-AML under two conditions (GelMA and control) to assess differential gene expression related to phenotype.
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-15359 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human mesenchymal stromal cells cultured in PEG hydrogels with and without FGF-2
FGF-2 is commonly used in culture media when growing mechenchymal stromal cells. Here, we cultured human MSCs from 3 donors with and without 50 ng/ml FGF-2 (Prepotech, human recombinant) in 3D PEG hydrogels, and analysed transcriptome changes by RNA sequencing.
ORGANISM(S): Homo sapiens 
2020-06-02 | E-MTAB-8510 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 4T1 mouse breast cancer cells cultured on soft vs stiff polyacrylamide hydrogels for 24 hours
The tumour microenvironment is a critical element involved in tumour progression and responsiveness to therapies. Using functionalized tunable stiffness hydrogel, mimicking the mechanical properties of healthy and tumour tissues, we explore how the stiffness of the microenvironment can influence can...
ORGANISM(S): Mus musculus 
2024-12-30 | E-MTAB-11487 | biostudies-arrayexpress
ProteomicsCharacterisation of decellularized extracellular matrix hydrogels
This study investigated the development and characterization of decellularized extracellular matrix (dECM) hydrogels tailored for the bio-fabrication of female reproductive tissues, specifically targeting cortex, endometrium, medulla, and oviduct tissues. We aimed to evaluate the cytocompatibility, ...
ORGANISM(S): Bos taurus (Bovine) 
2026-03-12 | PXD053248 | Pride
Bio-ink Hydrogels In vitro models Reproductive system 
ProteomicsCholangiocyte organoid culture in hydrogels from decellularized liver tissue
Culture of human cholangiocyte organoids in hydrogels derived from healthy liver extracellular matrix (LECM) extracts prepared from decellularized human livers are evaluated in an effort to establish a platform for production of cholangiocyte organoids for clinical regenerative applications. Human ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028417 | Pride
Human Regeneration Hydrogel Liver Cholangiocyte Organoid 
ProteomicsHuman Placenta Extracellular Matrix Hydrogels for wound healing
Injectable hydrogels derived from decellularized extracellular matrix (ECM) are emerging biomaterials for minimally invasive tissue repair. Among available sources, human placental tissue is appealing due to its abundance, ethical acceptability, and structural similarity to fetal tissue environments...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD065490 | Pride
Decellularization Regenerative medicine Human placenta Extracellular matrix Hydrogel 
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to batch variation, high cost, and...
ORGANISM(S): Sus scrofa (Pig) Mus musculus (Mouse) 
2022-02-10 | PXD023694 | Pride
Organoid Matrigel Lc-ms/ms 
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoid
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to22 batch variation, high cost, a...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-01-31 | PXD023705 | Pride
Gastrointestinal organoid Tissue extracellular matrix 
Sort   by:  
 Page size