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ProteomicsMultiomics analyses reveal B cell differentiation arrest and neutrophil hypogranulation in a patient with an immunodeficiency caused by a novel homozygous missense variant in HYOU1
The Hypoxia Upregulated Protein 1 (HYOU1) encodes an endoplasmic reticulum chaperone which is expressed in response to endoplasmic reticulum stress and contributes to cellular protection by restoring cell homeostasis. In this study, we report a patient with a novel homozygous variant in HYOU1 (NM_00...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD058947 | Pride
B cell deficiency Multiomics Neutrophil hypogranulation Hyou1 Immunodeficiency 
GenomicsThe Impact of HYOU1 Knockdown on Gene Expression in Hep3B Liver Cancer Cells
The Impact of HYOU1 Knockdown on Gene Expression in Hep3B Liver Cancer Cells
PRJNA1233328 | ENA
TranscriptomicsThe Impact of HYOU1 Knockdown on Gene Expression in Hep3B Liver Cancer Cells
In order to explore the role of HYOU1 in liver cancer cells and identify its downstream target genes, we utilized lentiviral technology to knock down HYOU1 expression and established a stable HYOU1 knockdown Hep3B liver cancer cell line. Gene expression profiling was then performed using two groups ...
ORGANISM(S): Homo sapiens 
2025-03-31 | GSE291417 | GEO
TranscriptomicsDiscovery of a Novel Class of Bioactive Molecules Suppressing Pathogenic Fibroblast Activation through Hyou1 Targeting
Fibroblasts play an important role in fibrosis, chronic inflammatory diseases (CIDs) and cancer. Targeting their pathogenicity is crucial, considering the limitations and side effects of existing biologic therapies that focus on inflammatory mediators (TNFα/IL-6). Herein, a multidisciplinary approac...
ORGANISM(S): Mus musculus 
2024-03-12 | GSE237395 | GEO
UnknownHYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA.
Not available
S-EPMC8107106 | biostudies-literature
GenomicsDiscovery of a Novel Class of Bioactive Molecules Suppressing Pathogenic Fibroblast Activation through Hyou1 Targeting
Discovery of a Novel Class of Bioactive Molecules Suppressing Pathogenic Fibroblast Activation through Hyou1 Targeting
PRJNA994878 | ENA
UnknownExpression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids.
Not available
S-EPMC7854178 | biostudies-literature
GenomicsBulk RNA sequencing analysis of a patient with an immunodeficiency caused by a novel homozygous missense variant in HYOU1
Bulk RNA sequencing analysis of a patient with an immunodeficiency caused by a novel homozygous missense variant in HYOU1
PRJEB95011 | ENA
TranscriptomicsBulk RNA sequencing analysis of a patient with an immunodeficiency caused by a novel homozygous missense variant in HYOU1
In this study, we report a patient with a novel homozygous variant in HYOU1 (NM_001130991.3:c.1331C>A, p.Pro444His), who was born to related parents and presented with combined immunodeficiency, failure to thrive, and hypoglycemia. We undertook a multiomics analysis combining transcriptomics, prote...
ORGANISM(S): Homo sapiens 
2025-08-25 | E-MTAB-15443 | biostudies-arrayexpress
UnknownOverexpression of HYOU1 is associated with cisplatin resistance and may depend on m6A modification in patients with cervical cancer.
Not available
S-EPMC11622003 | biostudies-literature
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