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ProteomicsTime-course of ischemia-reperfusion in a pig model
We have performed an unbiased, open-search analysis of the oxidative PTMs and quantitative multiplexed proteomics that take place in the pig ischemic heart tissue during the first 24h after I/R. We used 40 castrated male Large-White pigs weighing 30 to 40 kg. Closed-chest 40 min I/R was performed i...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-05-24 | PXD045771 | Pride
Ptms Ischemic heart tissue Ischemia reperfusion (i/r) Quantitative proteomics Pig 
ProteomicsProteomics analysis of myocardial tissue from ischemia/reperfusion (I/R) pig model treated with cardiosphere-derived cells (CDCs)
Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from s...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-12-22 | PXD070301 | Pride
Quantitative proteomics I/r pig model Tmt18plex Cardiosphere-derived cells 
TranscriptomicsA Gene Expression Atlas of the Domestic Pig
A Gene Expression Atlas of the Domestic Pig
ORGANISM(S): Sus scrofa 
2012-09-01 | E-MTAB-1183 | biostudies-arrayexpress
ProteomicsA scalable, clinically severe pig model for Duchenne muscular dystrophy
Large animal models for Duchenne muscular dystrophy (DMD) are indispensible for preclinical evaluation of novel diagnostic procedures and treatment strategies. To evaluate functional consequences of Duchenne muscular dystrophy (DMD) in skeletal muscle and myocardium, we used a new genetically engine...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-12-01 | PXD027772 | Pride
Proteomics Dmd Duchenne muscular dystrophy Pig Animal model 
TranscriptomicsThe regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure.
Following parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide (NO) r...
ORGANISM(S): Sus scrofa 
2008-01-14 | E-GEOD-6860 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of pig liver from neonatal pigs fed milk and soy formula
The majority of babies in the US are formula-fed instead of breast fed. There are major differences in the composition of formulas and breast milk and yet little is known about metabolic differences in babies as the result of feeding these very different diets and how that might affect development ...
ORGANISM(S): Sus scrofa 
2012-01-05 | E-GEOD-28349 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse GPI-deficient bone marrow cells in a mouse model of targeted Pig-a deletion
Somatic mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene causes glycosylphosphatidylinositol (GPI) anchor deficiency in humans with Paroxysmal Nocturnal Hemoglobinuria (PNH). Clinically, patients with PNH have intravascular hemolysis, venous thrombosis and bone marrow failur...
ORGANISM(S): Mus musculus 
2009-09-18 | E-GEOD-14561 | biostudies-arrayexpress
TranscriptomicsComprehensive transcriptome analysis of pig induced pluripotent stem cells by high-throughput sequencing
The wide application of pig disease model has caused a surge of interest in the study ofderivation of pig induced pluripotent cells (iPSCs). Here we performed genome-wide analysis of gene expression profiling by RNA-seq and small RNA-seq and DNA methylation profile by MeDIP-seq in pig iPSCs through ...
ORGANISM(S): Sus scrofa 
2015-09-17 | E-MTAB-2634 | biostudies-arrayexpress
TranscriptomicsPig SISP jejunal segments: Lactobacillus plantarum and msa/srt mutant strains vs control, perfusion 4 or 8 hours
Mannose-specific interactions of Lactobacillus plantarum 299v with jejunal epithelium were investigated using an in situ pig small intestinal segment perfusion (SISP) model. L. plantarum 299v wildtype strain was compared to two isogenic mutant strains either lacking the gene encoding for the mannose...
ORGANISM(S): Sus scrofa 
2010-05-25 | E-GEOD-9209 | biostudies-arrayexpress
TranscriptomicsExpression data from lung tissues of minipig with left lung ischemia-reperfusion
Lung ischemia-reperfusion (I/R) injury remains one of the common complications after various cardiopulmonary surgeries. I-R injury represents one potentially maladaptive response of the innate immune system which is featured by an exacerbated sterile inflammatory response triggered by tissue damage....
ORGANISM(S): Sus scrofa 
2015-12-07 | E-GEOD-75560 | biostudies-arrayexpress
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