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Proteomics2-dimensional thermal proteome profiling of HZ052
Identification of (off)-targets of HZ052, a new Hla inhibitor using 2-dimensional thermal proteome profiling
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD046735 | Pride
A549 
ProteomicsThe effect of an NAT10 inhibitor (remodelin) on inflammation-related genes in the treatment of thalamic hemorrhage based on proteomics data
Thalamic hemorrhage is a disease caused by hemorrhage of the thalamic brain parenchyma and is accompanied by an inflammatory response during development. NAT10 has been associated with a wide range of diseases. The aim of this study was to explore the molecular mechanisms associated with the use of ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-24 | PXD058910 | Pride
Nat10 Thalamic hemorrhage Tmt 
ProteomicsDCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug discovery. So far only a few ligases have been utilized for ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD046286 | Pride
Tmt Dcaf1 Tpd Protac 
ProteomicsiTRAq and TMTPro datasets Rescored with Prosit
Rescoring with Prosit predictions and percolator 6 different PRIDE submited datasets: 1- PXD017472 2- PXD017621 3- PXD002214 4- PXD021401 5- PXD027089 6- PXD024275
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-09 | PXD031575 | Pride
Human Tmtpro Prosit Itraq4 Mouse Itraq8 Tmt16plex Tmt18plex 
ProteomicsArabidopsis thaliana ASK1 proximity labeling upon Pst DC3000 infection
we used proximity labeling of ASK1, a core SCF adaptor, to profile dynamic changes in SCF-associated networks during Pseudomonas syringae infection. This analysis revealed widespread remodeling of F-box proteins and immune-related regulators, including several previously uncharacterized components.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-05 | PXD063820 | Pride
Skp1 Turboid Ask1 Proteasome Proximity labelling Arabidopsis 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
ProteomicsProteomics analysis of myocardial tissue from ischemia/reperfusion (I/R) pig model treated with cardiosphere-derived cells (CDCs)
Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from s...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-12-22 | PXD070301 | Pride
Quantitative proteomics I/r pig model Tmt18plex Cardiosphere-derived cells 
ProteomicsDRM6 and DLO1 TurboID-based proximity labelling proteomics
TurboID-based proximity labeling of DMR6 and DLO1 identified several candidate interactors, including a putative F-box protein that may contribute to their SCF-dependent turnover.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Nicotiana benthamiana 
2026-03-06 | PXD063821 | Pride
Skp1 Drm6 Salicylic acid Dlo1 Ask1 Proteasome Arabidopsis 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
ProteomicsSmall molecule induced STING degradation facilitated by the HECT ligase HERC4
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug discovery...
ORGANISM(S): Homo sapiens (Human) 
2024-04-12 | PXD046677 | Pride
Targeted protein degradation Herc4 Tmt Mgd Glue degrader Tpd Sting 
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