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TranscriptomicsTranscriptomic and proteomic profiling reveal insights of mesangial cell function in patients with IgA Nephropathy
IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The disease is characterized by galactose deficient IgA (gd-IgA) in the circulation forming immune complexes. The complexes are deposited in the glomerular mesangium leading to inflammation and loss of renal function, but the...
ORGANISM(S): Homo sapiens 
2017-07-03 | E-GEOD-93798 | biostudies-arrayexpress
TranscriptomicsThe molecular phenotype of endocapillary proliferation in IgA nephropathy and potential modulation by bioactive small molecules
Endocapillary proliferation is associated with higher risk of progressive disease in IgAN. To better understand molecular pathways involved in the development of endocapillary proliferation and to identify novel specific therapeutic targets, we evaluated the glomerular transcriptome of microdissecte...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-50469 | biostudies-arrayexpress
ProteomicsDetection of N‑glycoprotein associated with IgA nephropathy in urine as a potential diagnostic biomarker using glycosylated proteomic analysis
The present study aimed to clarify the potential diagnosis value of the urinary N-glycoproteins using mass spectrometry (MS) analysis in patients with IgA nephropathy (IgAN).
ORGANISM(S): Homo sapiens (Human) 
2023-08-13 | PXD041151 | Pride
Ms-based proteomics Urine Iga nephropathy Glycoproteins Biomarkers 
TranscriptomicsExpression data from human with IgA nephropathy (IgAN)
This SuperSeries is composed of the following subset Series: GSE35487: Expression data from human with IgA nephropathy (IgAN) [HG-U133A] GSE35488: Expression data from human with IgA nephropathy (IgAN) [HG-U133A_ENTREZG_10] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35489 | biostudies-arrayexpress
TranscriptomicsExpression data from human with IgA nephropathy (IgAN) [HG-U133A]
Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or h...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35487 | biostudies-arrayexpress
GenomicsSingle-cell transcriptomic analysis of PBMCs from IgAN patients
Single-cell transcriptomic analysis of PBMCs from IgAN patients
PRJNA1202919 | ENA
ProteomicsSerum Proteome Analysis of IgA Nephropathy  
Proteome comparison between IgAN patients who progressed (PR) and those who remained stable (non-progressors, NP) before clinical divergence.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065216 | Pride
Human Kidney Serum Igan 
TranscriptomicsAltered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I)...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-14795 | biostudies-arrayexpress
ProteomicsAntibody arrays for identification of biomarkers of Immunoglobulin A nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. However, biomarkers for predicting the progression or regression of IgAN remain a clinical challenge. In the present study, we aim to identify novel diagnostic and prognostic markers of IgAN. Using the cytokine anti...
ORGANISM(S): Homo sapiens 
2022-07-13 | E-MTAB-11972 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomic analysis of PBMCs from IgAN patients
IgA nephropathy (IgAN), the most common primary glomerulonephritis, is a significant cause of chronic kidney disease. While previous studies have highlighted the role of immune cells in IgAN development, the disease’s heterogeneous clinical presentation and prognosis have hindered a comprehensive un...
ORGANISM(S): Homo sapiens 
2026-01-21 | GSE285335 | GEO
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