Sort   by:  
 Page size 
TranscriptomicsIntegrated expression profiles of mRNA and miRNA in polarized primary murine microglia (miRNA)
The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from miRNA gene expression microarrays; mRNA expression profiles obtained from the same RNA s...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-49330 | biostudies-arrayexpress
TranscriptomicsIntegrated expression profiles of mRNA and miRNA in polarized primary murine microglia (mRNA)
The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from mRNA gene expression microarrays; miRNA expression profiles obtained from the same RNA s...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-49329 | biostudies-arrayexpress
ProteomicsHuman Cerebrospinal fluid LC-MSMS
Chronic Traumatic Encephalopathy (CTE) is a tauopathy that affects individuals with a history of repetitive mild traumatic brain injury, such as American football players. Initial neuropathologic changes in CTE include perivascular deposition of phosphorylated microtubule-associated protein tau (p-t...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD015358 | Pride
Cerebrospinal fluid Extracellular vesicles Lc-msmsms Chronic traumatic encephalopathy Tmt label 
ProteomicsProtein profiling of CAST.APP/PS1 mouse brain-derived Extracellular vesicles
Extracellular vesicles (EVs) are secreted by any neuronal cells in the central nervous system (CNS) for molecular clearance, cellular communications and disease spread in multiple neurodegenerative diseases, including Alzheimer’s disease (AD), although their exact molecular mechanism is poorly under...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022349 | Pride
App/ps1 mouse Extracellular vesicles Brain tissue Lc-msmsms Tmt label 
ProteomicsHuman and mouse brain, and human cerebrospinal fluid extracellular vesicles LC-MSMS
Extracellular vesicles (EVs) are a unified terminology of membrane-enclosed vesicular species ubiquitously secreted by almost every cell type and present in all body fluids. They carry a cargo of lipids, metabolites, nucleic acids and proteins for their clearance from cells as well as for cell-to-ce...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-02-17 | PXD017273 | Pride
Human Cerebrospinal fluid Lc-msms Extracellular vesicles Brain tissue Mouse Tmt label 
ProteomicsHuman iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis
The apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanistic underpinnings by which it alters human microglial function remain poorly understood. Here, we utilize CRISPR/Cas9-engineered isogenic human induced pluripotent ste...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD074177 | Pride
Extracellular vesicle Proteomics Ad Apoe Organoids Nfkb Microglia Human ipsc 
ProteomicsMouse brain-derived extracellular vesicles proteomics
P2x purinoreceptor 7 (P2RX7), an ATP gated ion-channel, is known to play a role in extracellular vesicles (EV) secretion. In this study we performed mass spectrometry of extracellular vesicles isolated from brain tissues (brain-derived EVs, BDEVs) of 9.5-months-old WT, PS19 and PS19/P2rx7-/- mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD065057 | Pride
Mouse Brain Extracellular vesicles Lc-ms/ms 
Sort   by:  
 Page size