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ProteomicsCMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here, we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-02 | PXD036366 | Pride
Cmtm4 Il-17 receptor signaling complex Il-17a Il-17rc 
ProteomicsT cells and adipocyte IL-17RC control fat innervation and thermogenesis
The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation1,2. The molecular basis of this bi-directional communication is unknown. Here we use thermogenic ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-02 | PXD017424 | Pride
Tmt based quantitative proteomics Murine brown adipose tissue 
GenomicsIL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis
IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis
PRJNA1431413 | ENA
UnknownInherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
Not available
S-EPMC4419340 | biostudies-literature
UnknownIdentification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Not available
S-EPMC2849293 | biostudies-literature
UnknownIL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
Not available
S-EPMC2897912 | biostudies-literature
TranscriptomicsIL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis
While dysbiosis and inflammation were previously implicated in cardiovascular diseases, the circuits of how microbiota drives distant perivascular innervation, neuroinflammation, and atherosclerosis remains unknown. Here, we report that IL-17RC signaling in the intestine protects from atherosclerosi...
ORGANISM(S): Mus musculus 
2026-03-11 | GSE322757 | GEO
UnknownIL-17A promotes Helicobacter pylori-induced gastric carcinogenesis via interactions with IL-17RC.
Not available
S-EPMC9813207 | biostudies-literature
UnknownIL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis.
Not available
S-EPMC5870983 | biostudies-literature
UnknownActivation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
Not available
S-EPMC3972892 | biostudies-literature
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