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TranscriptomicsExpression data from human monocyte-derived dendritic cells treated or not with interleukin 17A (IL-17A)
IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodelin...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-53163 | biostudies-arrayexpress
TranscriptomicsIL-17A influences essential functions of the monocyte / macrophage lineage and is involved in advanced murine and human atherosclerosis
Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated by cells of the monocyte/macrophage lineage. Interleukin-17A is a pro-inflammatory cytokine, which modulates immune cell trafficking and is involved inflammation in (auto)immune and infectious diseases. But t...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-60824 | biostudies-arrayexpress
Transcriptomics4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα a...
ORGANISM(S): Mus musculus 
2016-12-02 | E-MTAB-5218 | biostudies-arrayexpress
TranscriptomicsIL-17A plays a central role in the expression of psoriasis signature genes through induction of IkappaB-zeta in keratinocytes
In psoriasis lesions, a diverse mixture of cytokines is upregulated which influence each other generating a complex inflammatory situation. Although this is the case, the inhibition of Interleukin-17A (IL-17A) alone showed unprecedented clinical results in patients, indicating that IL-17A is a criti...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-77719 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
We examined the effect of IL-17 signaling pathway on extracellular matrix (ECM) expression and the involvement of IL-17 signaling pathway in pathogenesis of SSc. To identify differences in the expression pattern of ECM genes in IL-17A- or IL-17F-treated cells, we performed PCR array analysis, consis...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33581 | biostudies-arrayexpress
TranscriptomicsGene expression profile in 67NR tumor cell line
To assess whether IL-17 has the ability to change the behavior of 67NR tumor cell line, we analyzed the gene expression profiles of the 67NR cells lines treated or not with IL-17A using microarray analysis
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-2735 | biostudies-arrayexpress
ProteomicsIL-17A Alters Human Cortical Development and Induces Extracellular Matrix Remodeling in a 3D Ex Vivo Model of Maternal Immune Activation
Human brain development depends on the coordinated interaction of diverse cell types and extracellular matrix (ECM) components, essential for proper neurogenesis and cortical organization. Epidemiological and animal studies demonstrated that maternal immune activation (MIA) disrupts brain developmen...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD070178 | Pride
Human Lc-msms Cerebroids Neurodevelopment Maternal inflammation Extracellular matrix Il-17a 
TranscriptomicsGene expression profile of human epidermal keratinocytes in response to IFNgamma, IL-4, IL-6, IL-17A and IL-22
To understand the role of epidermal keratinocytes in immunopathology of skin diseases with predominant T helper (Th) cell responses, we measured the genome-wide transcriptional profile of human keratinocytes in response to IFNgamma, IL-4, IL-17A or IL-22, major cytokines produced by Th1, Th2, Th17 o...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-53751 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of colon and ileum tissue from naive wild type, MR1-/- and IL-17A-/- mice
Determination of differentially expressed genes in the proximal colon and distal ileum tissue in MR1 and IL-17A deficiency at steady-state. Tissue from naïve mice was harvested, total RNA extracted and subjected to RNASeq analysis.
ORGANISM(S): Mus musculus 
2018-03-31 | E-MTAB-6547 | biostudies-arrayexpress
ProteomicsProtein phosphorylations, mediated by pro-inflammatory cytokines IL-32g and IL-17A/F
Global kinase activity induced by cytokines IL-32g and IL-17A/F were determined using peptide arrays representing phophorylation targets The objective of this study was to identify common and unique phosphorylation targets of pro-inflammatory cytokines IL-32 and IL-17. These cytokines are associated...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28649 | biostudies-arrayexpress
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