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TranscriptomicsTranscription profiling of human imatinib-sensitive and imatinib-resistant cells compared in the absence of imatinib
Both imatinib-sensitive and imatinib-resistant cells were compared in the absence of imatinib. The resistant cells in the presence of imatinib were compared to the sample in the absence of imatinib. The sample from the resistant cells in the presence of imatinib was labelled in duplicate to assess f...
ORGANISM(S): Homo sapiens 
2003-11-30 | E-MEXP-21 | biostudies-arrayexpress
ProteomicsLIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance
Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we performed quantitative mass spectrometry comparing the proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD066618 | Pride
Imatinib K562 Tki resistance Lin28a Phosphoproteomics 
TranscriptomicsNoncoding RNA expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasa...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-33288 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients using Agilent-014698 Whole Human Genome 105K microarrays.
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34+ cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association betwe...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-21986 | biostudies-arrayexpress
TranscriptomicsProtein coding gene expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasa...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-33224 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasa...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-33290 | biostudies-arrayexpress
GenomicsGenomic profiling of imatinib resistant and sensitive K562 cells to obtain insights into imatinib resistance
Chronic myeloid leukemia (CML) epitomizes successful targeted therapy, with 86% of patients in the chronic phase treated with tyrosine kinase inhibitors (TKIs) attaining remission. However, resistance to TKIs occurs during treatment, and patients with resistance to TKIs progress to the acute phase c...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-11896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumour is predictive of rapid response to imatinib mesylate
Gene expression profiling using oligonucleotide microarrays performed on tumor samples obtained before and after imatinib mesylate (IM) therapy. Rapid responding (to IM) samples were compared to non-responding/stable disease samples as measured by CT scan measurements to identify a gene signature t...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-15966 | biostudies-arrayexpress
TranscriptomicsScleroderma and Gleevec treatment
Total RNA was extracted from skin biopsies before and after imatinib (Gleevec) treatment using Qiagen RNeasy fibrous tissue kit. RNA was amplified using the Ambion Amino Allyl MessageAmp II aRNA kit. Amplified skin RNA (labeled with Cy5) and amplified Stratagene Human Universal Reference RNA (labele...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-GEOD-11130 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of Saccharomyces cerevisiae to imatinib
Long-term effects of imatinib, a chemotherapy agent, on S. cerevisiae cells were investigated. Yeast cells were grown in the absence and presence of 400 mg/l imatinib in fully controlled bioreactors, in triplicates. Control cultures were described before, E-MTAB-6634.
ORGANISM(S): Saccharomyces cerevisiae 
2020-12-01 | E-MTAB-9042 | biostudies-arrayexpress
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