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ProteomicsUsing proteomics and transcriptomics to explore the potential gene regulatory network of immune checkpoint inhibitors-related myocarditis
Immune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great signifi...
ORGANISM(S): Homo Sapiens 
2023-02-02 | PXD039793 |
GenomicsSequencing of patient samples who received immune checkpoint inhibition WES NKI
DNA and RNA isolated from FFPE blocks of patients who received immune checkpoint inhibition (ICI) are sequenced with the aim to identify therapeutically tractable vulnerabilities in tumors to prevent ICI resistance.
EGAS00001003154 | EGA
GenomicsColitis associated with immune checkpoint inhibitors
Colitis associated with immune checkpoint inhibitors
PRJNA849977 | ENA
ModelsTsur2019 - Response of patients with melanoma to immune checkpoint blockade
This is a simple mathematical population model for pembrolizumab-treated advanced melanoma patients, used to predict the response of melanoma patients to immune checkpoint inhibitors.
2024-09-02 | BIOMD0000000838 | BioModels
Immuno-oncology 
TranscriptomicsRestoring PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance
Immune checkpoint inhibitors (ICIs) are a type of cancer treatment that work by targeting molecules on immune cells that can inhibit the immune system's ability to attack cancer cells. One such checkpoint molecule is PD-1, which is found on the surface of T cells (a type of immune cell) and helps to...
ORGANISM(S): Mus musculus 
2023-08-22 | E-MTAB-12872 | biostudies-arrayexpress
GenomicsColitis associated with immune checkpoint inhibitors [tissue_nuclei]
Colitis associated with immune checkpoint inhibitors [tissue_nuclei]
PRJNA849980 | ENA
GenomicsColitis associated with immune checkpoint inhibitors [tissue_cells]
Colitis associated with immune checkpoint inhibitors [tissue_cells]
PRJNA849981 | ENA
GenomicsColitis associated with immune checkpoint inhibitors [blood_cells]
Colitis associated with immune checkpoint inhibitors [blood_cells]
PRJNA849982 | ENA
GenomicsA Multifactorial Tumor and Immune Cell Profile Determines Response to Immune Checkpoint blockade in Melanoma
The complex crosstalk between tumor and immune cells during immune checkpoint blockade mandates the development of integrated models that interpret the anti-tumor immune response and predict clinical outcome. We have integrated genome-wide sequence and structural alterations with pre and on-therapy ...
EGAS00001004548 | EGA
ProteomicsULK1 as a novel therapeutic target to enhance immune checkpoint therapies against melanoma
Immune checkpoint inhibitors (ICIs) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. Interferon-gamma (IFNg) signaling and the expression of IFNg-stimulated genes correlate with...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035347 | Pride
Irf1 Interferon-gamma Ulk1 Melanoma Pd-l1 Signaling Immune checkpoint inhibitors 
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