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MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
MetabolomicsIntegrative of Single-Cell RNA Sequencing and Metabolomics Decipher the Imbalanced Lipid-Metabolism in Maladaptive Immune Responses during Sepsis
To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Machine learning algorithms were applied for screening hubgenes related to lipid metabolism. CIBERSORT and Single-sample GSEA were employed for assessing the immune cell infil...
2024-09-26 | MTBLS7315 | MetaboLights
MetabolomicsDietary iron attenuates Clostridioides difficile infection via modulating intestinal immune response and gut microbiota

Clostridioides difficile (C. difficile) causes antibiotic-associated diarrhea. Susceptibility to C. difficile infection (CDI) is largely affected by the gut microbiota, which in turn is influenced by diet. However, the mechanism underlying the interplay between diet and the gut mic...

2024-11-12 | MTBLS11336 | MetaboLights
MetabolomicsDual-Targeted Microspheres Reshape the Metabolic-immune Microenvironment and Reverse Multiple Dilemmas Post-embolization in Hepatocellular Carcinoma

Transarterial embolization (TAE) efficacy in hepatocellular carcinoma (HCC) is limited by post-embolization hypoxia-driven angiogenesis and metabolic reprogramming. To address these challenges, pH-responsive gelatin microspheres encapsulating zinc sulfide (ZnS) nanoparticles (ZnS@GMs) were develo...

2026-02-09 | MTBLS13720 | MetaboLights
ProteomicsSpatially variant immune infiltration scoring in human cancer tissues
The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity. However, immune cells exhibit a higher-level complexity that is typically...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035340 | Pride
Lung cancer imc 
GenomicsImmune Infiltration in Aggressive Papillary Craniopharyngioma: High infiltration But Low Action
Immune Infiltration in Aggressive Papillary Craniopharyngioma: High infiltration But Low Action
PRJNA892989 | ENA
GenomicsEvaluation of triple negative breast cancer with heterogeneous immune infiltration
Identification of potential RNA markers fir TILs infiltration in patients with triple negative breast cancer with heterogeneous immune infiltration.
EGAS00001007159 | EGA
ProteomicsUBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation
Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key...
ORGANISM(S): Homo Sapiens 
2026-01-28 | PXD073700 |
TranscriptomicsShcA is a Paracrine Integrator of the Adaptive Immune Response during Breast Cancer Progression
Using transgenic mouse models of breast cancer, we demonstrate that loss of ShcA signaling within mammary tumors results in extensive CD4+ T cell infiltration, activation and induction of a humoral immune response. Our studies reveal that ShcA signaling during early breast cancer progression is requ...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-18996 | biostudies-arrayexpress
ProteomicsSecretome analysis of Pancreatic Cancer Spheroid with myeloid cell infiltration
Pancreatic ductal adenocarcinoma (PDAC) is one of the most hypoxic, lethal, and treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with the abundance of myeloid cell infiltration and scare T cell infiltration, PDAC is considered a cold tumor. Using MiaPaCA-2 as a PDAC sphe...
ORGANISM(S): Homo sapiens (Human) 
2023-12-15 | PXD044177 | Pride
Human Spheroid Pancreatic cancer Pdac Miapaca2 Lc-ms/ms 
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