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ProteomicsSNX27 interactome during immune synapse formation
T lymphocyte recognition of antigenic peptides on the surface of antigen-presenting cells (APC) leads to immune synapse formation (IS). By analogy with the nervous synapse, this cell-cell communication model requires the formation of highly organized structures that delimit an active zone of membran...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD003628 | Pride
Snx27 Immune synapse Zo-2 T-lymphocyte Pdz 
ProteomicsT-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
The present dataset contains proteomics data from extracellular vesicles steadily released by donor matched, cultured human CD4+ and CD8+ T cells and from extracellular vesicles released within the immunological synapse.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033917 | Pride
T-cells Immunological synapse Extracellular vesicles 
TranscriptomicsMicroarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the trai...
ORGANISM(S): Mus musculus 
2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress
ProteomicsGalectin-8 facilitates B cell responses to surface-tethered antigens by promoting antigen extraction at the B cell synapse
Complete activation of B cells relies on their capacity to extract surface-tethered 35  antigens at the immune synapse by either exerting mechanical forces or promoting 36  their proteolytic degradation through lysosome secretion. Whether antigen extraction 37  can be tuned by local cues originating...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-14 | PXD011522 | Pride
B-lymphocytes Processing and presentation Polarity Mouse immunization Immune synapse Antigen extraction Galectin-8 
UnknownGerminal center B cells recognize antigen through a specialized immune synapse architecture.
Not available
S-EPMC4943528 | biostudies-literature
UnknownMethylation of immune synapse genes modulates tumor immunogenicity.
Not available
S-EPMC6994116 | biostudies-literature
ProteomicsIn situ delivery of immune-synapse-stabilizing NK cells for postoperative tumor intervention
Natural killer (NK) cells eliminate target cells by forming an immunological synapse (IS). This process, however, is frequently thwarted by their “kiss-and-run” behavior characterized by transient, abortive interactions. Here, we equip NK cell with multivalent ligands that resemble prehensile “arms”...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-26 | PXD073114 | Pride
Natural killer cells Immune synapse Spatiotemporal delivery Multivalent interaction Postoperative tumor intervention 
GenomicsImmune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells
Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells
PRJNA681602 | ENA
TranscriptomicsTop3M-NM-2 is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation
Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3M-NM-2 (Top3M-NM-2) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and know...
ORGANISM(S): Homo sapiens 
2013-08-04 | E-GEOD-47502 | biostudies-arrayexpress
UnknownTAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
Not available
S-EPMC4395477 | biostudies-literature
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