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MetabolomicsReversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies
Not available
ORGANISM(S): Mus musculus 
ST001838 | MetabolomicsWorkbench
TranscriptomicsSugar turns benefit of cholesterol into immune evasion in Helicobacter pylori infected C57BL/6 mice
Following the initial demonstration of Helicobacter pyloriâ??s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3878 | biostudies-arrayexpress
ProteomicsNew insights into hypoxia-driven metabolic, anti-apoptotic and immune evasion strategies of primary human myeloma cells
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via an intermediate stage, smoldering MM (SMM). The mechanisms of MM progression have ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-17 | MSV000084470 | MassIVE
TranscriptomicsTranscription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress
TranscriptomicsGlobal changes in Staphylococcus aureus gene expression in human blood provide insight into mechanisms of immune evasion and virulence
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote bacteremia and survival in human blood is ...
ORGANISM(S): Staphylococcus aureus 
2011-08-25 | E-GEOD-25454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat CF4+ T cells transfected with simian immunodeficiency virus Nef cells leads to a molecular profile of viral persistence and immune evasion.
Jurkat T cell line was transfected with SIV Nef controlled by an inducible promoter system. Nef was induced by addition of 10 micromolar pronasterone A and gene expression values were determined after 24 hrs. Control Jurkat cells were untransfected and treated with 10 micromolar pronasterone A and g...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4785 | biostudies-arrayexpress
GenomicsDNA Methylation loss coupled with mitotic cell division promotes immune evasion of tumours with high mutation load
Mitotic cell division increases tumour mutation burden and copy number load with a positive and inverse correlation, respectively, with the clinical benefit of immunotherapy. Markers of cell division correlate also with genomic demethylation involving methylation loss in late-replicating partial met...
EGAS00001003731 | EGA
ProteomicsE3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion
The ubiquitin-proteasome system maintains protein homeostasis, underpins the cell cycle and is dysregulated in cancer. However, the role of individual E3 ubiquitin ligases, which mediate the final step in ubiquitin-mediated proteolysis, remains incompletely understood. Identified through screening f...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-23 | PXD025237 | Pride
Immune evasion E3 ubiquitin ligase Melanoma 
TranscriptomicsThe SaeR/S Gene Regulatory System is Essential for Innate Immune Evasion by Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is problematic both in hospitals and the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S two-compo...
ORGANISM(S): Staphylococcus aureus 
2010-05-14 | E-GEOD-15067 | biostudies-arrayexpress
ModelsWilkie2013r - immune-induced cancer dormancy and immune evasion-resistance
The paper describes a model of immune-induced cancer dormancy and immune evasion with resistance. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hah...
2024-09-02 | BIOMD0000000752 | BioModels
Immuno-oncology 
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