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GenomicsFlexible chromatin loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire
The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates VH-DJH recombination by juxtaposing distal VH genes next to the DJH- rearranged gene segment in the proximal Igh domain. By high-resolution mapping of long-range interactions, we now demons...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-43008 | biostudies-arrayexpress
ProteomicsImmune repertoire after immunization as seen by next generation sequencing and proteomics
We study the repertoire of immunoglobulin sequences after immunization in a cohort of rats. Animals were immunized with dinitrophenol modified KLH or with recombinant human HuD. In the immune repertoire, and also in the matching proteomics data, we observe that the animals produce a repertoire that...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-10-04 | PXD006484 | Pride
Proteogenomics Ngs Mass spectrometry Immunization Immunoglobulins Immune repertoire 
GenomicsRevisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing
Immunoglobulin Repertoire Analysis in PGNMID
PRJEB88838 | ENA
ProteomicsNext-generation Serology by Mass Spectrometry:Readout of the SARS-CoV-2 Antibody Repertoire
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses new advances i...
ORGANISM(S): Homo Sapiens 
2022-09-24 | PXD028627 | panorama
GenomicsCharacterizing adjuvants’ effects at the murine immunoglobulin repertoire level
Characterizing adjuvants’ effects at the murine immunoglobulin repertoire level
PRJNA951738 | ENA
TranscriptomicsAntibody mRNA-seq repertoire sequencing to study relapses after B-cell depletion therapy
Rituximab (RTX) is widely used as a first-line therapeutic strategy for patients affected by immune thrombocytopenia (ITP). However, a large proportion of patients relapse after successful treatment. The present NGS assay was done to help find the cause for this relapse on the immune repertoire leve...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9953 | biostudies-arrayexpress
ProteomicsExtensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs
B cells are crucial players in the pathogenesis of multiple sclerosis (MS), however, limited information is available on peripheral immunoglobulin (Ig) repertoires of people with MS (pwMS) in comparison to healthy individuals and during different treatments. Next generation sequencing of Ig heavy ch...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD075641 | Pride
Immunoglobulin proteome Keywords: multiple sclerosis (ms) Disease modifying drugs (dmds) Epstein-barr virus (ebv) Immunoglobulin repertoire B cells 
GenomicsHomo sapiens
Immunoglobulin repertoire sequencing of hu420143
PRJNA260976 | ENA
GenomicsImmunoglobulin library preparation for NGS
High-quality immunoglobulin library preparation for germline inference and repertoire expression analysis.
PRJEB30386 | ENA
GenomicsImmunoglobulin library preparation for NGS
High-quality immunoglobulin library preparation for germline inference and repertoire expression analysis.
PRJEB31256 | ENA
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