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TranscriptomicsHDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact m...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-67733 | biostudies-arrayexpress
TranscriptomicsExpression of miR-196a in Huntington's disease transgenic (HD) mice
We intend to screen altered genes after overexpression of miR-196a in HD transgenic mice. Two transgenic mouse lines were used in this study, including HD transgenic mice and HD transgenic mice overexpressing miR-196a. The mice were all at approximate 12 months of age. At this point, HD transgenic ...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-47500 | biostudies-arrayexpress
TranscriptomicsEarly transcriptional changes linked to naturally occurring Huntington's disease mutations in human embryonic stem cells
Multiple human embryonic stem (ES) cell lines derived from blastocysts diagnosed as carrying the mutant huntingtin gene by pre-implantation diagnosis were used to explore early developmental changes in gene expression. How mutant huntingtin impacts on signalling pathways in the pre-symptomatic perio...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-34201 | biostudies-arrayexpress
GenomicsMutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors
Huntington's Disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N-terminus of the huntingtin (Htt) protein. Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results f...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54443 | biostudies-arrayexpress
TranscriptomicsContinuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.
In Huntington’s disease (HD), expanded HTT CAG repeat length correlates strongly with age at motor onset, indicating that it determines the rate of the disease process leading to diagnostic clinical manifestations. Similarly, in normal individuals, HTT CAG repeat length is correlated with biochemica...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-34721 | biostudies-arrayexpress
ProteomicsNative MS and intact-protein MS datasets for NreB and NreB_PAS supporting the study “A labile sulfur ligand in a three-cysteine-coordinated [2Fe-2S] cluster mediates sulfide sensing in NreB”
This ProteomeXchange dataset contains native mass spectrometry and intact-protein mass spectrometry data generated in support of the manuscript “A labile sulfur ligand in a three-cysteine-coordinated [2Fe-2S] cluster mediates sulfide sensing in NreB”. The dataset includes intact-protein MS measureme...
ORGANISM(S): Bacillus licheniformis DSM 13 = ATCC 14580 
2026-04-15 | PXD076861 | Pride
Nreb_pas Gsh Nreb Fe-s cluster Nahs Native ms Sulfide sensing Bruker impact hd [2fe-2s] Intact protein ms 
TranscriptomicsNrf2-related oxidative stress response and impaired dopamine biosynthesis in a PC12 cell model of Huntington’s disease
Huntington’s disease (HD) is a devastating disease for which currently no therapy is available. It is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD gene, resulting in an expansion of polyglutamines at the N-terminal end of the encode...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-10581 | biostudies-arrayexpress
TranscriptomicsFlagellin_Illumina_Microarray
the aim of the study was to assess the role of flagellin in the interaction bwetween Salmonella Typhi and host cells. A macrophage-like cell line (THP1) and an epithelial cell line (Hep2) were infected with S. Typhi expressing one of three flagellin variants: Hd, Hj or Hz66. A non-flagellated muta...
ORGANISM(S): Homo Sapiens 
2014-07-01 | E-MTAB-2395 | biostudies-arrayexpress
ProteomicsProteomic profiling of circulating extracellular vesicles from COVID-19 patients and their impact on innate Vdelta2 T-cell response.
Introduction: The crosstalk between immune cells through plasma extracellular vesicles (EVs) during SARS-CoV-2 infection may represent a significant determinant of clinical course in COVID-19 patients. EVs from SARS-CoV-2 virus-infected cells deliver their informational content to immune cells impli...
ORGANISM(S): Homo sapiens (Human) 
2026-02-10 | PXD072061 | Pride
Covid-19 Extracellular vesicles Plasma Lc-ms/ms 
TranscriptomicsTranscription profiling of Arabidopsis mutant REVOLUTA (HDZIPIII) to identify downstream targets
The establishment of ad/abaxial polarity is a fundamental event in plant development. It is critical for correct polar development of the leaf (the upper portion of the leaf is chloroplast rich and optimized for light capture while the lower portion is optimized for gas exchange) and for creating a...
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-7003 | biostudies-arrayexpress
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