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The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-like phenotypes through treatment with all-trans retinoic acid (ATRA). After differentiation, these cell lines are extensively utilized as in vitro models to study various aspects of neuronal cell biology. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD046900 | Pride
The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-like phenotypes through treatment with all-trans retinoic acid (ATRA). After differentiation, these cell lines are extensively utilized as in vitro models to study various aspects of neuronal cell biology. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD046871 | Pride
ChIP-seq to define bindings sites for SOX11 and Input in the neuroblastoma cell line IMR-32
ORGANISM(S): Homo sapiens 
Non-stressed and UV-stressed IMR-32 cells were subjected to HITS-CLIP to monitor nELAVL binding changes during AD progression Nonstressed and stressed IMR-32 cells were UV-irradiated and subjected to nELAVL HITS-CLIP (detailed desription in accompanying paper)
ORGANISM(S): Homo sapiens 
IMR-32 cells were subjected to lentiviral YRNA infection or nELAVL RNAi and/or UV stress followed by RNAseq analysis to monitor RNA level changes RNA from IMR-32 cells was Trizol extracted, Ribominus selected and submitted for high-throughput sequencing.
ORGANISM(S): Homo sapiens 
ATAC-seq to define open chromatin in the neuroblastoma IMR-32 cell line.
ORGANISM(S): Homo sapiens 
ATAC-seq in neuroblastoma IMR-32 cell line
SOX11 ChIP-seq in neuroblastoma cell line IMR-32
ChIP-seq to define bindings sites for TBX2, MYCN, H3K27ac, H3K4me1, H3K4me3 and Input in the cell lines IMR-32, CLB-GA, NGP, IMR-5/75, GI-M-EN, CHP-212, and IMR-5.
ORGANISM(S): Homo sapiens 
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