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MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsMetabolomic comparison of RA vs healthy monocytes undergoing different ex vivo activation conditions

Rheumatoid arthritis (RA) monocytes are primed for inflammatory activation, but their disease-intrinsic molecular features have not been systematically profiled across omics layers. We aimed to define RA-associated alterations in primary human monocytes using an integrated multi-omics approach un...

2026-10-16 | MTBLS14227 | MetaboLights
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
GenomicsIn vivo co-transplant gene expression
In vivo co-transplant gene expression
PRJNA734656 | ENA
TranscriptomicsTranscription profiling of mouse acute lymphoblastic leukemia in vivo after allogeneic or syngeneic bone marrow transplantation
This study compared gene expression in murine bcr-abl positive acute lymphoblastic leukemia cells in vivo in allogeneic BMT recipients compared to syngneneic BMT recipients. Experiment Overall Design: The goal of the experiment was to compare gene expression in leukemia cells that were in either an ...
ORGANISM(S): Mus musculus 
2009-09-06 | E-GEOD-17497 | biostudies-arrayexpress
Proteomicsin vivo environment swiftly restricts human pancreatic progenitors towards monohormonal identity via a HNF1A/HNF4A mechanism
Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy aimed at improving or curing certain forms of diabetes. Nevertheless, despite important recent advances, the efficient production of functionally mature β-cells is yet to be achieve...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD015955 | Pride
Human Ipsc Alginate In vivo transplant 
GenomicsDirect-induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplant in vivo
Direct-induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplant in vivo
PRJNA824530 | ENA
UnknownLong-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion.
Not available
S-EPMC6802423 | biostudies-literature
TranscriptomicsTranscriptional profiles by deep sequencing (RNA-seq) of in vivo-generated mouse iPSCs, in vitro-generated mouse iPSCs, and mouse ESCs
We have generated M-bM-^@M-^\reprogrammableM-bM-^@M-^] transgenic mice that ubiquitously express the four Yamanaka factors in an inducible manner. Transitory induction of the transgene results in multiple teratomas emerging from a variety of organs, thus indicating that full reprogramming into iPSCs...
ORGANISM(S): Mus musculus 
2013-09-12 | E-GEOD-48364 | biostudies-arrayexpress
MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
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