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TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
TranscriptomicsStudy of the effect on indoxyl sulfate on endothelial gene expression
The aim of this study is to determine the molecular mechanism by which indoxyl sulfate acts on endothelial cells. Endothelial cells (HUVECs) were incubated with medium containing indoxyl sulfate at concentration found in chronic kidney disease patients (1mM). Since indoxyl sulfate is a potassium sa...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-34259 | biostudies-arrayexpress
ProteomicsIndoxyl sulfate and p-cresyl sulfate directly promote vascular calcification via activation of inflammation and coagulation pathways
Vascular calcification contributes to high cardiovascular mortality in chronic kidney disease (CKD) patients. An association between the uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) and cardiovascular disease has been suggested. This study provides strong etiological evidence for in...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-13 | PXD012582 | Pride
Indoxyl sulfate Chronic kidney disease Vascular calcification Inflammation Hyperglycemia Coagulation P-cresyl sulfate Itraq-8plex 
MetabolomicsLuminal metabolome profiles of mice developed dextran sulfate sodium (DSS) colitis
Not available
ORGANISM(S): Mus musculus 
ST001250 | MetabolomicsWorkbench
TranscriptomicsStudy of the effect on indoxyl sulfate on endothelial gene expression
The aim of this study is to determine the molecular mechanism by which indoxyl sulfate acts on endothelial cells. Endothelial cells (HUVECs) were incubated with medium containing indoxyl sulfate at concentration found in chronic kidney disease patients (1mM). Since indoxyl sulfate is a potassium sal...
ORGANISM(S): Homo sapiens 
2014-01-01 | GSE34259 | GEO
TranscriptomicsThe molecular basis of the renal and vascular consequences of Uremia
Background. Chronic renal failure is characterized by progressive renal scarring and accelerated cardiovascular disease. In animal models, this is thought to be due to non-dialyzable uremic toxins M-bM-^@M-^S small, protein-bound molecules normally secreted via Organic Anion Transporters (OATs) in t...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-45709 | biostudies-arrayexpress
GenomicsTranscriptional profiling of human monocytes treated with indoxyl sulfate (IS) or p-cresyl sulfate (PCS)
Transcriptional profiling of human monocytes treated with indoxyl sulfate (IS) or p-cresyl sulfate (PCS)
PRJNA649416 | ENA
ProteomicsProteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: mechanisms of endothelial dysfunction in chronic kidney disease
Introduction: Cardiovascular pathology is the main cause of death in patients with chronic kidney disease (CKD). CKD is associated with the accumulation of uremic toxins in the bloodstream due to their difficult elimination by renal substitution therapy. Indoxyl sulfate (IS) is one of the most abund...
ORGANISM(S): Homo sapiens (Human) 
2024-11-29 | PXD050628 | Pride
Cardiovascular disease Chronic kidney disease Indoxyl sulfate Proteomics Endothelial dysfunction Extracellular vesicles 
Unknownp-Cresyl sulfate and indoxyl sulfate in hemodialysis patients.
Not available
S-EPMC2798868 | biostudies-literature
UnknownRenal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD.
Not available
S-EPMC3805062 | biostudies-literature
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