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ProteomicsInner ear hair cell proteome
The mammalian inner ear subserves auditory and vestibular sensations via highly specialized cells and proteins. We show that sensory hair cells (HCs) employ hundreds of uniquely or highly expressed proteins for processes involved in transducing mechanical inputs, stimulating sensory neurons, and mai...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-23 | MSV000079756 | MassIVE
ProteomicsReprocessed: Chick utricle hair bundles and utricular epithelium—Orbitrap
This is a reanalysis of PXD000104. Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo Orbitrap Elite mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002445 | Pride
Vestibular Hair cells Stereocilia Utricle 
ProteomicsRat utricle hair bundles and whole utricles—LTQ
Purified utricle hair bundles and utricular epithelium from P3-P7 rat inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo LTQ mass spectrometer for protein detection.
ORGANISM(S): Rattus norvegicus (Rat) 
2015-11-17 | PXD002416 | Pride
Vestibular Hair cells Stereocilia Utricle 
ProteomicsMouse utricle hair bundles and whole utricles—Velos
Purified utricle hair bundles and utricular epithelium from P21-P25 mouse inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo LTQ Velos mass spectrometer for protein detection.
ORGANISM(S): Mus musculus (Mouse) 
2015-11-17 | PXD002415 | Pride
Vestibular Hair cells Stereocilia Utricle 
ProteomicsChick utricle hair bundles and utricular epithelium—Velos
Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo LTQ Velos mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002414 | Pride
Vestibular Hair cells Stereocilia Utricle 
TranscriptomicsTranscriptomes of the Cochlear Inner and Outer Hair Cells
The transcriptome is the complete set of all RNA transcripts produced by the genome in a cell and reflects the genes that are being actively expressed. Transcriptome analysis is essential for understanding the genetic mechanism controlling the phenotype of a cell. Using DNA microarray technique we e...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-56866 | biostudies-arrayexpress
ProteomicsMouse wild-type and Anxa5-null utricles and hair bundles
The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, present at ~15,000 copies per stereocilium, which is ~2% of the total protein there. Although seven other annexin genes are expressed in mouse utricle...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-09 | PXD003005 | Pride
Hair cells Annexins Vestibular Stereocilia 
GenomicsRNA-sequencing of Adult Mouse Inner Hair Cells and Outer Hair Cells of the organ of Corti
RNA-sequencing of Adult Mouse Inner Hair Cells and Outer Hair Cells of the organ of Corti
PRJNA436761 | ENA
ProteomicsProteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cells
In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory information to the brain. The presynaptic machinery responsible for neurotransmitter release in IHC synapses includes proteins such as the multi-C2-domain protein otoferl...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-09 | PXD046664 | Pride
Proteomics Inner hair cells Trafficking Vglut3 Vesicles 
TranscriptomicsTranscription profiling of mouse discrete microdissected inner ear tissues from E9 to E15 at half-day intervals.
The inner ear in mammals is derived from a simple ectodermal thickening called the otic placode. Through a series of complex morphological changes, the placode forms the mature inner ear comprising of the auditory organ (cochlea) and the vestibular/balance organs (utricle, saccule, and three semi-ci...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7536 | biostudies-arrayexpress
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