Sort   by:  
 Page size 
MetabolomicsBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights
TranscriptomicsAdenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRN...
ORGANISM(S): Homo sapiens 
2016-09-05 | E-GEOD-60217 | biostudies-arrayexpress
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
GenomicsInosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis
PRJNA762272 | ENA
ProteomicsMulti-omics analysis of the bladder and its sensitivity to inosine in a rat model of spinal cord injury
This study investigates the molecular changes in the bladder following spinal cord injury (SCI) in rats and the impact of inosine treatment using a multi-omics approach. We discovered the activation of PARP (Poly(ADP-ribose) polymerase) in response to SCI, a previously unrecognized phenomenon, and i...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD046096 | Pride
Multi-omics Spinal cord injury Inosine Bladder Rat 
ProteomicsInosine induces context-dependent recoding and translational stalling
To test how inosine in a codon is translated, we synthesized short reporter-transcripts coding for an N-terminal Flag-tag and a test-peptide containing inosine in one defined codon. All codons containing inosines in at least one position were tested. Codons that would lead to ambiguous translation p...
ORGANISM(S): synthetic construct 
2018-11-06 | PXD010329 | Pride
Lc-msms A-to-i editing Rna modification Epitranscriptome Mrna-translation Adar 
GenomicsInosine enhances mitochondria respiration to promote cancer survival under starvation
Inosine enhances mitochondria respiration to promote cancer survival under starvation
PRJNA936873 | ENA
TranscriptomicsNew targets of Drosophila adenosine deaminase acting on RNA (dADAR)
The aim of this experiment is to identify new targets of Drosophila adenosine deaminase acting on RNA (dADAR) by enriching Inosine-containing mRNA (I-mRNA) from wild type (C-S) and dADAR mutant flies and then hybridization with Drosophila cDNA arrays.
ORGANISM(S): Drosophila melanogaster 
2010-06-05 | E-GEOD-529 | biostudies-arrayexpress
ProteomicsHuman tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
The modification of adenosine to inosine at the wobble position (I34) of tRNA anticodons is an abundant and essential feature of eukaryotic tRNAs. The expansion of inosine-containing tRNAs in eukaryotes followed the transformation of the homodimeric bacterial enzyme TadA, which generates I34 in tRNA...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD025024 | Pride
Transfer rna  inosine  low-complexity proteins  mucin-like domain  cell adhesion 
GenomicsInhibiting tumor cell-intrinsic UBA6 by inosine augments tumor immunogenicity
Inhibiting tumor cell-intrinsic UBA6 by inosine augments tumor immunogenicity
PRJNA864795 | ENA
Sort   by:  
 Page size