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GenomicsHistone Demethylase UTX-1 Regulates the Caenorhabditis elegans Lifespan by Targeting the Insulin/IGF-1 Signaling Pathway
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1...
ORGANISM(S): Caenorhabditis elegans 
2011-11-22 | E-GEOD-29896 | biostudies-arrayexpress
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
ProteomicsThe Insulin/IGF Signaling Cascade Modulates SUMOylation to Regulate Aging and Proteostasis in C. elegans.
In this project we asked how reducing the activity of the insulin/IGF signaling (IIS) cascade by knocking down the expression of daf-2, affects global protein SUMOylation of C. elegans. We found that among other proteins, IIS reduction lowers the SUMOylation of CAR-1, a protein that negatively regul...
ORGANISM(S): Caenorhabditis elegans 
2018-06-06 | PXD010011 | Pride
Sumoylation Aging Lifespan C. elegans Germline Insulin/igf signaling (iis) Proteostasis 
ProteomicsIIS-mediated modulation of DIGs proteome in C. elegans.
Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis) and elevates stress resistance of worms, flies and mammals. How these functions are orchestrated across the organism is only partially understood. One prominent group of IIS-regulated encode for lipi...
ORGANISM(S): Caenorhabditis elegans 
2018-05-09 | PXD009704 | Pride
Detergent resistant granules. Aging Insulin/igf signaling C. elegans 
TranscriptomicsRNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated
In this study we have investigated the effect of loss of math-33 activity on DAF-16-mediated target gene regulation in C. elegans under conditions of reduced Insulin/IGF-1 signaling (IIS). Using whole nematode RNA sequencing experiments we found that the daf-2(e1370)-mediated induction and repressio...
ORGANISM(S): Caenorhabditis elegans 
2016-06-22 | E-GEOD-70117 | biostudies-arrayexpress
GenomicsRegulation of germline proteostasis by insulin/IGF-1 signaling
Regulation of germline proteostasis by insulin/IGF-1 signaling
PRJNA1078387 | ENA
TranscriptomicsRegulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domains, thus playing a critical role in signal transduc...
ORGANISM(S): Drosophila melanogaster 
2016-03-30 | E-MTAB-4612 | biostudies-arrayexpress
ProteomicsInsulin Signaling Regulates Longevity Through Protein Phosphorylation in Caenorhabditis elegans
Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic...
ORGANISM(S): Caenorhabditis Elegans 
2021-06-10 | PXD020440 |
GenomicsFOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling
FOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling
PRJNA573686 | ENA
TranscriptomicsFOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling
A hallmark of aging is immunosenescence, a decline in immune function that appeared to be inevitable. Surprisingly, here we show that genetic inhibition of DAF-2/insulin/IGF-1 receptor drastically delays immunosenescence and even rejuvenates immunity in C. elegans. We find that p38 mitogen activated...
ORGANISM(S): Caenorhabditis elegans 
2021-02-26 | GSE137861 | GEO
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